Victor Faundez, MD, PhD

Professor

Department of Cell Biology

Office: 446 Whitehead Research Bldg

Phone: 404 727-3900

Email: vfaunde@emory.edu

Office Location:

Mailing Address:

Emory University - Department of Cell Biology

615 Michael St, 1941/001/1AF

Atlanta, GA 30322

Research Focus

We are interested in understanding complex neurological disorders using  cell biology, genetic, and systems biology tools. We are focused on microdeletion syndromes, genetic defects of human metal transporters and  BLOC-1-dependent trafficking to the synapse. Our studies of the BLOC-1 complex in Drosophila and mouse indicate that the BLOC-1 complex is required to target synaptic vesicle membrane proteins from endosomes to the synapse and to specify a reserve pool of vesicles.  We postulate that the BLOC-1 pathway contributes to the pathogenesis of neurodevelopmental disorders. Genetics studies have identified the gene encoding dysbindin (DTNBP1), a BLOC-1 subunit, as a schizophrenia susceptibility gene.  The cellular and molecular mechanisms that require dysbindin-BLOC-1 in neurons are mostly unexplored and they are one of the present interests of our laboratory as they promise to provide clues of the cellular basis of neuropsychiatric disorders.

Lab Personnel

1) Avanti Gokhale, Assistant Professor

2) Amanda Freeman, Assistant Professor

3) Stephanie Zlatic, Postdoc

4) Skye Comstra, Graduate Student

5) Jennifer Larimore, Adjunct Professor (Agnes Scott College)

6) Cortnie Hartwig, Adjunct Professor (Kennesaw State University)

Publications