Hyojung Choo, PhD
Cell Biology, Emory School of Medicine
Office: 542 Whitehead Research Bldg
Emory University - Department of Cell Biology
615 Michael St
Atlanta, GA 30322
Craniofacial muscles are essential muscles for normal daily life. They are involved in facial expressions (facial muscles), blinking and eye movement (eye muscles), as well as speaking and eating (tongue and pharyngeal muscles).
Interestingly, craniofacial muscles have differential susceptibility to several muscular dystrophies. For example, craniofacial muscles are the most affected muscles in oculopharyngeal muscular dystrophy but the least affected muscles in Duchenne muscular dystrophy. Among craniofacial muscles, dysfunction of
The mechanisms of skeletal muscles are of interest here because skeletal muscle cells are multinucleated cells. Typically, skeletal muscle cells contain hundreds of nuclei in a single cell since they are generated by fusion of muscle precursor cells during development or by fusion of
- How the niche cells (fibro/adipogenic progenitor cells) affect satellite cell fusion in craniofacial muscles compared to limb muscles.
- How muscle cells maintain a constant myonuclear number through myonuclear addition (satellite cell fusion) and myonuclear turnover.
- How myonuclear homeostasis is involved in the pathology of oculopharyngeal muscular dystrophy.
Our research also involves differentiation of skeletal muscle progenitor cells from human patient induced pluripotent stem cells (iPSC) as a model system of neuromuscular