Selected Publications
Saberi S*, Stauffer JE*, Jiang J*, Garcia S, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez M, Pizzo D, Cleveland DW, and Ravits J. (2018) Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely colocalize with TDP-43 in dendrites of repeat expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol 135(3):459-474. [Link]
Jiang J*, Zhu Q*, Gendron TF*, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. (2016) Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs. Neuron 90(3):535-50. [Link]
Jiang J, Cleveland DW. (2016) Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72. Neuron 92(6):1160-3. [Link]
Torres-Salazar* D, Jiang J*, Divito CB, Garcia-Olivares J, Amara SG. (2015) A mutation in transmembrane domain 7 (TM7) of excitatory amino acid transporters disrupts the substrate-dependent gating of the intrinsic anion conductance and drives the channel into a constitutively open state. J Biol Chem. 290(38):22977-90. [link]
Jiang J, Shrivastava IH, Watts SD, Bahar I, Amara SG. (2011) Large collective motions regulate the functional properties of glutamate transporter trimers. Proc Natl Acad Sci USA 108(37):15141-6. [link]
Jiang J, Amara SG. (2011) New views of glutamate transporter structure and function: advances and challenges. Neuropharmacology 60(1):172-81. [link]
Shrivastava IH, Jiang J, Amara SG, Bahar I. (2008) Time-resolved mechanism of