Kevin Moses
Associate Professor of Cell Biology
(404) 727-8799 - phone
(404) 727-4717 - fax
kmoses@cellbio.emory.edu
Kevin Moses - before and after his recent hair cut (panels NOT to same scale)
Research Interests
I am interested in the developmental biology of the nervous system. The workings of the complex nervous systems of higher animals (such as ourselves) is surely the greatest remaining mystery in biology. In such systems function is related to structure, and thus it is of interest how the many nerve cells achieve their correct cell-types and positions in space. In recent years the most rapid advances in developmental biology (and biology in general) have come from a reductionist and genetic approach. Thus I seek to approach nervous system development by the use of a simple model system, with powerful genetic tools: the compound eye of Drosophila melanogaster.
Education
Research and Professional Experience
Honors
Current Federal Advisory Committee Memberships
Publications:
Research Papers
1] Chia, W., Howes, G., Martin, M., Meng, Y. B., Moses, K. and Tsubota, S. (1986). Molecular analysis of the yellow locus of Drosophila. EMBO J. 5, 3597-3605.
2] Moses, K., Ellis,
M. C. and Rubin, G. M. (1989).
The glass gene encodes a zinc-finger protein required by
Drosophila photoreceptor cells. Nature 340,
531-536.
3] Moses, K., Heberlein,
U. and Ashburner, M. (1990). The
Adh gene promoters of Drosophila melanogaster and
Drosophila orena are functionally conserved and share features
of sequence structure and nuclease-protected sites. Mol. Cell.
Biol. 10, 539-548.
4] Moses, K. and Rubin,
G. M. (1991). glass encodes
a site-specific DNA-binding protein that is regulated in response
to positional signals in the developing Drosophila eye.
Genes Dev. 5, 583-593.
5] Baker, N. E., Moses, K., Nakahara, D., Ellis,
M. C., Carthew, R. W. and Rubin, G. M.
(1992). Mutations on the second chromosome affecting the Drosophila
eye. J. Neurogenet. 8, 85-100.
6] Ma, C., Zhou, Y., Beachy, P. A. and Moses, K. (1993). The segment polarity gene hedgehog
is required for progression of the morphogenetic furrow in the
developing Drosophila eye. Cell 75, 927-938.
7] Tio, M., Ma, C. and Moses, K. (1994). spitz, a Drosophila homolog
of transforming growth factor-a, is required in the founding photoreceptor
cells of the compound eye facets. Mech. Dev. 48,
13-23.
8] Porter, J. A., von Kessler, D. P., Ekker, S. C.,
Young, K. E., Lee, J. J., Moses, K. and Beachy, P. A. (1995). The product of Hedgehog autoproteolytic
cleavage active in local and long-range signaling. Nature
374, 363-366.
9] Ma, C. and Moses, K.
(1995). wingless and patched are negative regulators
of the morphogenetic furrow and can affect tissue polarity in
the developing Drosophila compound eye. Development
121, 2279-2289.
10] Ma, C., Liu, H., Zhou, Y. and Moses, K.
(1996). Identification and characterization
of autosomal genes that interact with glass in the developing
Drosophila eye. Genetics 142, 1199-1213.
11] Liu, H., Ma, C. and Moses, K. (1996). Identification and functional characterization
of conserved promoter elements from glass: a retinal development
gene of Drosophila. Mech. Dev. 56, 73-82.
12] Tio, M. and Moses, K.
(1997). The Drosophila TGFa homolog Spitz acts in photoreceptor
recruitment in the developing retina. Development 124,
343-351.
13] Reifegerste, R., Ma, C. and Moses, K. (1997). A polarity field is established early
in the development of the Drosophila compound eye. Mech.
Dev. 68, 69-79.
14] Kumar, J. P., Tio, M., Hsiung, F., Akopyan, S.,
Gabay, L., Seger, R., Shilo, B.-Z. and Moses, K. (1998). Dissecting the roles of the Drosophila
EGF receptor in eye development and MAP kinase activation. Development
125, 3875-3885.
15] Brennan, C. A., Ashburner, M. and Moses, K. (1998). Ecdysone pathway is required for furrow
progression in the developing Drosophila eye. Development
125, 2653-2664.
16] Nagaraj, R., Pickup, A. T., Howes, R., Moses,
K., Freeman, M. and Banerjee, U.
(1999). Role of the EGF receptor pathway in growth and patterning
of the Drosophila wing through the regulation of vestigial.
Development 126, 375-985.
17] Brennan, C. A., Li, T. R., Bender, M., Hsiung,
F. and Moses, K. (2001).
Broad-complex, but not Ecdysone receptor, is required for progression
of the morphogenetic furrow in the Drosophila eye. Development
128, 1-11.
18] Kumar, J. P. and Moses, K. (2001). EGF Receptor and Notch Signaling Act Upstream
of Eyeless/Pax6 to Control Eye Specification. Cell 104,
687-697.
19] Kumar, J. P. and Moses, K. (2001). The EGF Receptor and Notch Signaling Pathways
Control the Initiation of the Morphogenetic Furrow During Drosophila
Eye Development. Development 128, 2689-2697.
20] Hsiung, F., Griffis, E. A., Pickup, A., Powers,
M. A. and Moses, K. (2001).
Function of the Drosophila TGF-a homolog Spitz is controlled by
Star and interacts directly with Star. Mech. Dev. 107,
13-23
21] Kumar,
J. P. and Moses, K. (2001). Expression of Evolutionarily Conserved
Eye Specification Genes during Drosophila Embryogenesis. Genes Dev.
Evol. 211, 406-414.
22] Kumar,
J. P., Wilkie, G. S., Tekotte, H., Moses, K. and Davis, I. (2001).
Perturbing nuclear transport in Drosophila eye imaginal discs causes
specific cell adhesion and axon guidance defects. Dev. Biol. 240. 315-325.
23] Kumar JP, Hsiung F, Powers M and Moses K (2003) Nuclear Translocation of Activated MAP Kinase is Developmentally Regulated in the developing Drosophila Eye. Development 130, 3703-3714.
24] Jin P, Zarnescu DC, Zhang F, Pearson CE, Lucchesi JC, Moses K and Warren ST (2003) RNA-Mediated Neurodegeneration Caused by the Fragile X Premutation rCGG Repeats in Drosophila. Neuron 39, 739-747.
25] Zarnescu D, Jin P, Nakamoto M, Dockendorff T, Feng
Y, Jongens T, Warren S and Moses K (2003) Fragile X and Lgl proteins form a
functional complex in fly and mouse neural development. Current Biology
(submitted).
Other Publications
1] Moses, K. and Ashburner, M. (1985). Period piece for Drosophila. Nature 315, 98.
2] Moses,
K. (1991). The role of transcription factors in the developing
Drosophila eye. Trends Genet. 7, 250-255.
3] Heberlein, U. and Moses, K. (1995). Mechanisms of Drosophila retinal
morphogenesis: the virtues of being progressive. Cell
81, 987-990.
4] Tio, M., Ma, C. and Moses, K. (1996). Extracellular
regulators and pattern formation in the developing Drosophila
retina. Biochem. Soc. Symp. 62, 61-75.
5] Kumar, J. and Moses, K. (1997). Transcription factors in eye development:
a gorgeous mosaic? Genes Dev. 11, 2023-2028.
6] Reifegerste, R. and Moses, K. (1999). Genetics of epithelial polarity and pattern
in the Drosophila retina. BioEssays 21, 275-285.
7] Moses, K. (2000).
Drosophila Eye: Progressive Neural Development. Encyclopedia
of Life Sciences
8] Brennan, C. A. and Moses, K. (2000). Determination of Drosophila photoreceptors:
timing is everything. Cell. Mol. Life Sci. 57, 195-214.
9] Kumar, J. P. and Moses, K., Cell Fate Specification in the Drosophila
Retina, in Vertebrate Eye Development, Fini, E., Editor.
2000, Springer-Verlag: Berlin, Heidelberg, New York. p. 93-114.
10] Kumar,
J. P. and Moses, K. (2001). Eye specification in Drosophila: perspectives
and implications. Semin. Cell. Dev. Biol. 12(6), 469-474.
11] Moses, K., Drosophila Eye Development.
Results and Problems in Cell Differentiation, ed. Granderath, S. 2002, Heidelberg:
Springer-Verlag.
12] Kowalczyk AP and Moses K (2002) Photoreceptor Cells in Flies and Mammals: Crumby Homology? Dev Cell 2, 253-254.
13] Hsiung F and Moses K (2002) Retinal development in Drosophila: specifying the first neuron. Hum Mol Genet 11, 1207-1214.
14] Jones C and Moses K (2003) Cell cycle regulation and cell-type specification in the developing Drosophila compound eye. Semin. Cell. Dev. Biol. (In Press).
15] D'Costa
A and Moses K (2003) Looking up: regional patterning in the Fly eye. Dev.
Cell 5, 665-666.
Popular Science (not peer reviewed)
1] Moses, K. (1995). Where eyes begin - the morphogenetic furrow. Science Spectra 1(2), 20-25.
2] Moses, K. (1997). Patterns in Evolution: the New Molecular
View (book review). Science Spectra 1(10), 76-78.
3] K. Moses, (2000) Time, Love, Memory: A Great Biologist
and His Quest for the Origins of Behavior (book review). Science
Spectra 22 70-72
4] K. Moses (2001) "What all the buzz is
about" - review of "Fly: an experimental
life" by Martin Brookes (book review). Nature Biotech.
(in press)K. Moses and M. Ashburner, (1985) Nature
315 98,. Period piece for Drosophila.
