Welcome to the Shur laboratory
Department of Cell Biology
Emory University School of Medicine
Publications
Shur, B. and Roth, S. 1973. The localization and potential function of glycosyltransferases in chick embryos. Amer. Zool. 13: 1129-1135.
Seliger, H.H., Biggley, W.H. and Shur, B. 1973. Light inhibition of mechanically stimulable light in bioluminescent dinoflagellates. In International Conference on Chemiluminescence and Bioluminescence, M.J. Cormier, D.M. Hercules, and J. Lee, eds. Plenum Press, NY pp. 495.
Shur, B.D. and Roth, S. 1975. Cell surface glycosyltransferases. Biochim. Biophys. Acta 415: 473-512.
Roth, S., Barbera, A.J., Shur, B.D. and Marchase, R.B. 1975. The location and nature of molecules potentially involved in morphogenesis of the developing nervous system. In Extracellular Matrix Influences on Gene Expression, H.C. Slavkin and R.C. Greulich, eds. Academic Press, NY, pp. 473-477.
Roth, S. and Shur, B. 1975. The biochemistry of cell recognition and migration. In Mead Johnson Symposium in Perinatal and Developmental Medicine VII. Clinical and Biological Aspects of Malformations, pp. 24-29.
Durr, R., Shur, B. and Roth, S. 1977. Sperm-associated sialyltransferase activity. Nature. 265: 547-548.
Roth, S., Shur, B.D. and Durr, R. 1977. A possible enzymatic basis for some cell recognition and migration phenomena in early embryogenesis. In Cell and Tissue Interactions, J. Lash and M. Burger, eds. Raven Press, NY, pp. 209-223.
Shur, B.D., DeLong, G.R. and Roth, S. 1977. Increased alkaline phosphatase activity in reeler cerebella. Exp. Neurol. 54: 128-140.
Shur, B.D. 1977. Cell surface glycosyltransferases in gastrulating chick embryos. I. Temporally and spatially specific patterns of four endogenous glycosyltransferase activities. Dev. Biol. 58: 23-39.
Shur, B.D. 1977. Cell surface glycosyltransferases in gastrulating chick embryos. II. Biochemical evidence for a surface localization of endogenous glycosyltransferase activities. Dev. Biol. 58: 40-55.
Pierce, M., Shur, B.D., Marchase, R.B. and Roth, S. 1978. Glycosyltransferase activities in developing chick embryos: Potential roles in cell recognition and migration. In Birth Defects: Original Article Series, The National Foundation, 14: 317-326.
Shur, B.D. 1978. Molecular Control of Proliferation and Differentiation. The Thirty-Fifth Symposium of The Society for Developmental Biology, J. Papaconstantinou and W.J. Rutter, eds. Academic Press, NY. Quart. Rev. Biol. 53: 448-449. (book review)
Shur, B.D. 1979. Developmental Biology: Embryos, Plants, and Regeneration, J.W. Brookbank, ed. Harper and Row, Publisher, NY. Quart. Rev. Biol. 54: 181-183. (book review)
Shur, B.D. and Bennett, D. 1979. A specific defect in galactosyltransferase regulation on sperm bearing mutant alleles of the T/t-locus. Dev. Biol. 71: 243-259.
Shur, B.D., Oettgen, P. and Bennett, D. 1979. UDPgalactose inhibits blastocyst formation in the mouse: Implications for the mode of action of T/t-complex mutations. Dev. Biol. 73: 178-181.
Shur. B.D. 1980. The Biochemistry of Glycoproteins and Proteoglycans. W.J. Lennarz, ed. Plenum Press, NY. Science. 209: 1010-1011. (book review)
Shur, B.D. 1981. Galactosyltransferase activities on mouse sperm bearing multiple tlethal and tviable haplotypes of the T/t-complex. Genetical Research 38: 225-236.
Shur, B.D., Vogler, M. and Kosher, R.A. 1982. Changes in endogenous cell surface galactosyltransferase activity during in vitro limb bud chondrogenesis. Exp. Cell Res. 137: 229-237.
Shur, B.D. 1982. Cell surface glycosyltransferase activities during normal and mutant (T/T) mesenchyme migration. Dev. Biol. 91: 149-162.
Shur, B.D. 1982. Evidence that galactosyltransferase is a surface receptor for poly(N) acetyllactosamine glycoconjugates on embryonal carcinoma cells. J. Biol. Chem. 257: 6871-6878.
Shur, B.D. 1982. Galactosyltransferase defects in reeler mouse brains. J. Neurochem. 39: 201-209.
Shur, B.D. 1982. Cell surface glycosyltransferase activities during fertilization and early embryogenesis. In The Glycoconjugates, Vol. III, M. Horowitz, ed. Academic Press, NY, pp. 145-185.
Shur, B.D. and Hall, N.G. 1982. Sperm surface galactosyltransferase activities during in vitro capacitation. J. Cell Biol. 95: 567-573.
Shur, B.D. and Hall, N.G. 1982. A role for mouse sperm surface galactosyltransferase in sperm binding to the egg zona pellucida. J. Cell Biol. 95: 574-579.
Shur, B.D. 1983. Embryonal carcinoma cell adhesion. The role of surface galactosyltransferase and its 90K lactosaminoglycan substrate. Dev. Biol. 99: 360-372.
Shur, B.D. 1983. The role of cell surface galactosyltransferase in embryonal carcinoma cell adhesion. In Teratocarcinoma Stem Cells, Tenth Cold spring Harbor Symposium on Cell Proliferation, pp. 185-195.
Shur, B.D. 1984. The receptor function of galactosyltransferase during cellular interactions. Molec. Cell. Biochem. 61: 143-158.
Shur, B.D., Bayna, E.M., Runyan,R.B., Reichner, J.S., Scully, N.F., Maxwell, G.D. and Kurt-Jones, E. 1985. The receptor function of cell surface glycosyltransferases during mammalian fertilization, development and immune recognition. In Cellular and Pathological Aspects of Glycoconjugate Metabolism. H. Dreyfus, ed. INSERM 126: 393-408.
Lopez, L.C., Bayna, E.M., Litoff, D., Shaper, N.L., Shaper, J.H. and Shur, B.D. 1985. The receptor function of mouse sperm surface galactosyltransferase during fertilization. J. Cell Biol. 101: 1501-1510.
Shur, B.D. 1986. The receptor function of galactosyltransferase during mammalian fertilization. Adv. Exp. Med. Biol. 207: 79-93.
Runyan, R.B., Maxwell, G.D. and Shur, B.D. 1986. Evidence for a novel enzymatic mechanism of neural crest cell migration on extracellular glycoconjugate matrices. J. Cell Biol. 102: 432-441.
Bayna, E.M., Runyan, R.B., Scully, N.F., Reichner, J., Lopez, L.C. and Shur, B.D. 1986. Cell surface galactosyltransferase as a recognition molecule during development. Molec. Cell. Biochem. 72:141-151.
Scully, N.F., Shaper, J.H. and Shur, B.D. 1987. Spatial and temporal expression of cell surface galactosyltransferase during mouse spermatogenesis and epididymal maturation. Dev. Biol. 124:111-124.
Lopez, L.C. and Shur, B.D. 1987. Redistribution of the mouse egg receptor on sperm following the acrosome reaction. J. Cell Biol. 105: 1663-1670.
McLaughlin, J.M. and Shur, B.D. 1987. Binding of caput epididymal mouse sperm to the zona pellucida. Dev. Biol. 124: 557-561.
Scully, N.F. and Shur, B.D. 1988. Stage specific increase in surface galactosyltransferase activity during spermatogenesis in t-bearing mice. Dev. Biol. 125: 195-199.
Macek, M.B. and Shur, B.D. 1988. Protein-carbohydrate complementarity in mammalian gamete recognition. Gamete Research 20: 93-109.
Eckstein, D.J. and Shur, B.D. 1988. Cell surface galactosyltransferase interaction with laminin during cell migration on basal lamina. Altered Glycosylation in Tumor Cells, UCLA Symposium, pp. 217-229.
Hathaway, H. and Shur, B.D. 1988. Novel cell surface receptors during mammalian fertilization and development. BioEssays 9: 153-158.
Bayna, E.M., Shaper, J.H. and Shur, B.D. 1988. Temporally specific involvement of ß1,4 cell surface galactosyltransferase during mouse embryo morula compaction. Cell 53: 145-157.
Runyan, R.B., Versalovic, J. and Shur, B.D. 1988. Functionally distinct laminin receptors mediate cell adhesion and spreading: The requirement for surface galactosyltransferase in cell spreading. J. Cell Biol. 107: 1863-1871.
Shur, B.D. and Neely, C.A. 1988. Plasma membrane association, purification and characterization of mouse sperm ß1,4 galactosyltransferase. J. Biol. Chem. 263: 17706-17714.
Lopez, L.C. and Shur, B.D. 1988. Comparison of two independent cDNA clones reported to encode ß1,4 galactosyltransferase. Biochem. Biophys. Res. Commun. 156: 1223-1229.
Tatum, S.M., Kurt-Jones, E.A., Shur, B.D. and Lindquist, R.R. 1988. Inhibitors of cytotoxic T lymphocyte galactosyltransferase inhibit cytotoxic T lymphocyte interaction with their target cells. Immunobiology of HLA 2: 572-574.
Shur, B.D. 1989. Galactosyltransferase as a recognition molecule during fertilization and development. In The Molecular Biology of Fertilization. H. Schatten and G. Schatten, eds. Academic Press, New York, pp. 37-71.
Eckstein, D.J. and Shur, B.D. 1989. Laminin induces the expression of cell surface galactosyltransferase to lamellipodia on migrating cells. J. Cell Biol. 108: 2507-2517.
Lopez, L.C., Maillet, C., Oleszkowicz, K., and Shur, B.D. 1989. Cell surface and Golgi pools of ß1,4 galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiation. Molec. Cell. Biol. 9: 2370-2377.
Shur, B.D. 1989. Glycoconjugates as mediators of cellular interactions during development. Current Opinion in Cell Biology 1: 905-912.
Shur, B.D. 1989. Expression and function of cell surface galactosyltransferase. Biochem. Biophys. Acta Reviews on Biomembranes 988: 389-409.
Begovac, P.C. and Shur, B.D. 1990. Cell surface galactosyltransferase mediates the initiation of neurite outgrowth on laminin. J. Cell Biol. 110: 461-470.
Youakim, A. and Shur, B.D. 1990. The relationship between Golgi and cell surface ß1,4 galactosyltransferase. J. Cellular Biochem. 111: 107-114.
Shur, B.D. and Scully, N.F. 1990. Elevated galactosyltransferase activity on t-bearing sperm segregates with T/t-complex distorter loci-2. Genetical Research 55: 177-181.
Marchase, R.B., Burkart, M.F., Clarke, B.L., Shur, B.D. and Shaw, D.R. 1991. ß-Phosphorothioate analogues of nucleotide sugars are resistant to hydrolytic degradation and utilized efficiently by glycosyltransferases. Analytical Biochem. 197: 40-46.
Fayrer-Hosken, R. A., Caudle, A.B. and Shur, B.D. 1991. Galactosyltransferase activity is restricted to the plasma membranes of equine and bovine sperm. Molec. Reprod. Devel. 28: 74-78.
Begovac, P.C., Hall, D. and Shur, B.D. 1991. Laminin fragment E8 mediates PC12 cell neurite outgrowth by binding to cell surface ß1,4 galactosyltransferase. J. Cell Biol. 113: 637-644.
Macek, M.B., Lopez, L.C., and Shur, B.D. 1991. Aggregation of ß1,4 galactosyltransferase on mouse sperm induces the acrosome reaction. Dev. Biol. 147: 440-444.
Hathaway, H., Runyan, R.B., Khounlo, S. and Shur, B.D. 1991. Purification and characterization of avian ß1,4 galactosyltransferase: comparison with the mammalian enzyme. Glycobiology 1: 211-221.
Lopez, L.C., Youakim, A., Evans, S. and Shur, B.D. 1991. Evidence for a molecular distinction between cell surface and Golgi forms of ß1,4 galactosyltransferase. J. Biol. Chem. 266: 15984-15991.
Hathaway, H.J. and Shur, B.D. 1991. Galactosyltransferase functions as a cell surface receptor during cell migration and neural development. The Cell (Japanese) 23: 35-42.
Shur, B.D. 1991. Cell surface ß1,4 galactosyltransferases: twenty years later. Glycobiology 1: 563-575.
Miller, D. J., Cross, N.L., Vazquez-Levin, M. and Shur, B.D. 1992. The role of sperm galactosyltransferase in fertilization: presence and possible function in humans and other mammals. In Comparative Spermatology - 20 Years After. Baccetti, B., ed., Raven Press, pp. 569-574.
Shur, B.D. 1992. Molecular basis of mammalian fertilization. In Post-Graduate Course, American Society of Andrology, 17th Annual Meeting. Overstreet, J.W., ed., pp. 21-29.
Hathaway, H. and Shur, B.D. 1992. Cell surface ß1,4-galactosyltransferase functions during neural crest cell migration and neurulation in vivo. J. Cell Biol. 117: 369-382.
Eckstein, D.J. and Shur, B.D. 1992. Cell surface ß1,4-galactosyltransferase is associated with the detergent-insoluble cytoskeleton on migrating mesenchymal cells. Exp. Cell Res. 201: 83-90.
Miller, D.J., Macek, M.B., and Shur, B.D. 1992. Complementarity between sperm surface ß1,4-galactosyltransferase and egg coat ZP3 mediates sperm-egg binding. Nature 357: 589-593.
Shur, B.D. 1993. Cell surface galactosyltransferase. In Guidebook to the Extracellular Matrix and Adhesion Proteins. Kreis, T. and Vale, R., eds., Sambrook and Tooze Publishers, pp. 125-127.
Youakim, A. and Shur, B.D. 1993. The effects of overexpression of ß1,4 galactosyltransferase on glycoprotein biosynthesis in F9 embryonal carcinoma cells. Glycobiology 3: 155-163.
Pratt, S.A. and Shur, B.D. 1993. ß1,4-Galactosyltransferase expression during spermatogenesis: stage-specific regulation by t alleles and uniform distribution in +-spermatids and t-spermatids. Dev. Biol. 156: 80-93.
Evans, S., Lopez, L.C. and Shur, B.D. 1993. Dominant negative mutation in cell surface ß1,4 galactosyltransferase inhibits cell-cell and cell-matrix interactions. J. Cell Biol. 120: 1045-1057.
Maillet, C.M. and Shur, B.D. 1993. Uvomorulin, LAMP-1 and laminin are substrates for cell surface ß1,4 galactosyltransferase on F9 embryonal carcinoma cells: comparisons between wild-type and mutant 5.51 att-cells. Exp. Cell Res. 208: 282-295.
Pratt, S.A., Scully, N.F. and Shur, B.D. 1993. Cell surface ß1,4-galactosyltransferase on primary spermatocytes facilitates their initial adhesion to Sertoli cells in vitro. Biol. Reprod. 49: 470-482.
Miller, D.J., Gong, X and Shur, B.D. 1993. Sperm require ß-N-acetylglucosaminidase to penetrate through the egg zona pellucida. Development 118: 1279-1289.
Shur, B.D. 1993. Glycosyltransferases as cell adhesion molecules. Current Opinion in Cell Biology 5: 854-863.
Miller, D.J., Gong, X., Decker, G. and Shur, B.D. 1993. Egg cortical granule N- acetylglucosaminidase is required for the mouse zona block to polyspermy. J. Cell Biol. 123: 1431-1440.
Appeddu, P.A. and Shur, B.D. 1994. Molecular analysis of cell surface of ß1,4 galactosyl-transferase function during cell migration. Proc. Natl. Acad. Sci.USA 91: 2095-2099.
Maillet, C. and Shur, B.D. 1994. Perturbing cell surface ß-(1,4)-galactosyltransferase on F9 embryonal carcinoma cells arrests growth and induces laminin synthesis. J. Cell Sci. 107: 1713-1724.
Cooke, S.V. and Shur, B.D. 1994. Cell surface ß1,4-galactosyltransferase: expression and function. Develop, Growth & Differ. 36: 125-132.
Miller, D.J. and Shur, B.D. 1994. Molecular basis of fertilization in the mouse. Seminars in Developmental Biology 5: 255-264.
Youakim, A., Hathaway, H.J., Miller, D.J., Gong, X. and Shur, B.D. 1994. Overexpressing sperm surface ß1,4 galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions. J. Cell Biol. 126: 1573-1584.
Appeddu, P.A. and Shur, B.D. 1994. Control of stable lamellipodia formation by expression of cell surface ß1,4 galactosyltransferase cytoplasmic domains. J. Cell Sci. 107: 2535-2545.
Youakim, A. and Shur, B.D. 1994. Alteration of oligosaccharide biosynthesis by genetic manipulation of glycosyltransferases. Annals of Nezv York Academy of Science 745: 331-335.
Hinton, D. and Shur, B.D. 1994. Molecular analysis of cell surface ß1,4 galactosyltransferase expression and function. TIGG 6: 375-385.
Youakim, A., Dubois, D. and Shur, B.D. 1994. Localization of long form ß1,4 galactosyltransferase to the plasma membrane and Golgi complex in 3T3 and F9 cells by immunofluorescence confocal microscopy. Proc. Natl. Acad. Sci. USA 91: 10913-10917.
Nguyen, T., Hinton, D. and Shur, B.D. 1994. Expressing murine ß1,4 galactosyltransferase in HeLa cells produces a cell surface galactosyltransferase dependent phenotype. J. Biol. Chem. 269: 28000-28009.
Shur, B.D. 1994. Glycobiology: The beginning of a sweet tale. Current Biology 4: 996-999.
Begovac, P.C., Shi, Y.-X., Mansfield, D. and Shur, B.D. 1994. Evidence that cell surface ß1,4-galactosyltransferase galactosylates an underlying laminin substrate during 3T3 fibroblast migration. J. Biol. Chem. 269: 31793-31799.
Huang, Q., Shur, B.D. and Begovac, P.C. 1995. Overexpressing cell surface ß1,4 galactosyltransferase in PC12 cells increases neurite formation on laminin. J. Cell Sci. 108: 839-847.
Dubois, D. and Shur, B.D. 1995. Cell surface ß1,4 galactosyltransferase: a signal transducing receptor? Adv. Exp. Med. Biol. 376: 105-114.
Evans, S.C., Youakim, A. and Shur, B.D. 1995. Biological consequences of targeting ß1,4-galactosyltransferase to two different subcellular compartments. BioEssays 17: 261-268.
Hinton, D., Evans, S. and Shur, B.D. 1995. Altering the expression of cell surface ß1,4 galactosyltransferase modulates cell growth. Exp. Cell Res. 219: 640-649.
Gong, X., Dubois, D. H., Miller, D.J. and Shur, B.D. 1995. Activation of a G-protein complex by aggregation of ß1,4-galactosyltransferase on the surface of sperm. Science 269: 1718-1721.
Hathaway, H.J. and Shur, B.D. 1996. Mammary gland morphogenesis is inhibited in transgenic mice that overexpress cell surface ß1,4-galactosyltransferase. Development 122: 2859-2872.
Hathaway, H.J. and Shur, B.D. 1997. Transgenic approaches to glycobiology. In Glycosciences: Status and Perspectives H.-J. Gabius and S. Gabius, eds., Chapman and Hall, pp. 507-517.
Lu, Q., Hasty, P. and Shur, B.D. 1997. Targeted mutation in ß1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality. Dev. Biol. 181: 257-267.
Huszar, G., Sbracia, M., Vigue, L., Miller, D.J., and Shur, B.D. 1997. Sperm plasma membrane remodeling during spermiogenetic maturation in men: relationship among plasma membrane ß1,4-galactosyltransferase, cytoplasmic creatine phosphokinase, and creatine phosphokinase isoform ratios. Bio. Reprod. 56: 1020-1024.
Lu, Q. and Shur, B.D. 1997. Sperm from ß1,4-galactosyltransferase null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly. Development 124: 4121-4131.
Shur, B.D., Evans, S.C. and Lu, Q. 1998. Cell surface galactosyltransferase: current issues. Glycoconjugate J. 15: 537-548.
Shur, B.D. 1998. Is sperm galactosyltransferase a signaling subunit of a multimeric gamete receptor? Biochem. Biophys. Res. Commun. 250: 537-543.
Shur, B.D. 1999. Zona pellucida-induced signal transduction via sperm surface ß1,4-galactosyltransferase. In The Male Gamete: From Basic Science to Clinical Applications Gagnon, C., ed., Cache River Press, pp. 213-225.
Shur, B.D. 1999. Cell surface galactosyltransferase. In Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins. Kreis, T. and Vale, R., eds., Sambrook and Tooze Publishers, pp. 163-166.
Johnson, F.M. and Shur, B.D. 1999. The level of cell surface ß1,4-galactosyltransferase I influences the invasive potential of murine melanoma cells. J. Cell Sci. 112: 2785-2795.
Shur, B.D. 1999. Initiating Development. Cell 98: 713-714. (book review)
Wassler, M.J. and Shur, B.D. 2000. Clustering of cell surface ß1,4 galactosyltransferase I induces transient tyrosine phosphorylation of focal adhesion kinase and loss of stress fibers. J. Cell Sci. 113: 237-245.
Avilés, M., Okinaga, T., Shur, B.D. and Ballesta, J. 2000. Differential expression of glycoside residues in the mammalian zona pellucida. Mol. Reprod. Dev. 57: 296-308.
Nixon, B., Lu., Q., Wassler, M., Foote, C., Ensslin, M., and Shur, B.D. 2001. Galactosyltransferase function during mammalian fertilization. Cells Tissues and Organs 168: 46-57.
Tergowski, M., Wassler, M., Shur, B.D. and Schatten, G. 2001. Subcellular localization of ß1,4-galactosyltransferase on bull sperm and its function during sperm-egg interactions. Mol. Reprod. Dev. 58:236-244.
Shi, X., Amindari, S., Paruchuru, K., Skalla, D., Shur, B.D. and Miller, D.J. 2001. Cell surface ß1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling, Development 128:645-654.
Wassler, M., Foote, C., Gelman, I., and Shur, B.D. 2001. Functional interaction between the SSeCKS scaffolding protein and the cytoplasmic domain of ß1,4-galactosyltransferase. J. Cell Sci. 114:2291-2300. (article featured as an editorial highlight)
Rodeheffer, C. and Shur, B.D. 2002. Targeted mutations in b1,4 galactosyltransferase I reveal its multiple cellular functions. Biochim. Biophys. Acta Reviews 1573:258-270.
Talbot, P., Shur, B.D. and Myles, D.G. 2003. Cell adhesion and fertilization: Steps in oocyte transport, sperm-zona pellucida interactions and sperm-egg fusion. Biol Reprod. 68:1-9.
Hathaway, H.J., Evans, S.C., Dubois, D.H., Foote, C.I, Elder, B.H. and Shur, B.D. 2003. Mutational analysis of the cytoplasmic domain of ß1,4-galactosyltransferase I: influence of phosphorylation on cell surface expression. J. Cell Sci. 116:4319-4330.
Ensslin, M.A. and Shur, B.D. 2003. Identification of mouse sperm SED1, a bi-motif EGF repeat and discoidin domain protein involved in sperm-egg binding. Cell 114:405-417. (featured article of the issue & mini-review topic; featured in Nature 425:33)
Rodeheffer, C. and Shur, B.D. 2004. Sperm from b1,4-galactosyltransferase I-null mice exhibit precocious capacitation. Development 131:491-501. (article featured as an editorial highlight)
Rodeheffer, C. and Shur, B.D. 2004. Identification of a novel, ZP3-independent egg coat ligand that facilitates initial sperm-egg adhesion. Development 131:503-512. (article featured as an editorial highlight)
Shur, B.D., Ensslin, M.A. and Rodeheffer, C. 2004. Sperm-egg binding. Current Opinion in Cell Biology, invited review, in press
Shur, B.D., Rodeheffer, C. and Ensslin, M.A. 2004. Mammalian fertilization. Current Biology, invited Quick Guide, in press