THE LABORATORY

For all those who are fascinated by the magic of the infinitely small, hidden in the bosom of the living being are millions of palpitating cells whose only demand for the surrender of their secret, and with it the halo of fame, is a lucid and tenacious intelligence to contemplate them, to admire and to understand them. - - - Ramón Cajal, 1923.

Curiosity drives the research in Zheng laboratory. Our work focuses on the signal transduction and cytoskeletal mechanisms that underlie axon guidance and regeneration, synapse formation and plasticity, and trafficking defects in neurodegenerative diseases. A major strength of our lab is the employment of advanced molecular/cellular imaging and manipulation approaches, which enable us to investigate spatiotemporally restricted signaling and cytoskeletal activities that govern and regulate a wide range of neuronal responses associated with neuronal development, function, and disorders. Our research goal is to provide a mechanistic understanding of the cell biology underlying these crucial developmental events, as well as to gain substantial knowledge on the molecular and cellular basis for brain abnormality and disorders.

Zheng laboratory is a part of the Department of Cell Biology, Emory University School of Medicine. We are also a member of Emory Center for Neurodegenerative diseases (CND). Physically, we are located on the fifth floor of the Whitehead Biomedical Research Building. Students and postdoctoral fellows in the lab receive not only basic training in developmental neurobiology, but also multidisciplinary skills, including primary neuronal culture, electrophysiological recording, high-resolution light & super-resolution microscopy, single molecular imaging and manipulation, whole brain imaging, and much more.  This is a very exciting time  for neuroscience as we start to get handles on many neurological disorders and diseases that have victimized human being for centuries.    It is also an exciting time for the laboratory. We are currently expanding and research positions are available! (view the announcement).  Interested persons should contact us directly.  

我们实验室坐落在美国乔治亚洲亚特兰大的埃默里大学(Emory University)的细胞生物系。 研究重点是集中在神经发育,疾病,和修复的细胞骨架和信号传导机理 (Cytoskeletal and signal transduction mechanisms). 现阶段主要研究神经发育过程中神经轴纤维的生长和导向(Axon growth and guidance), 神经连结的可塑性(Synaptic plasticity), 和胞内的运输缺陷 (trafficking defects)在神经衰竭性疾病 (neurodegenerative diseases), 包括老年痴呆症(Alzheimer’s Disease)中的作用. 我们的主要研究手段包括了各种细胞成像技术,从高分辨度高精度胞内离子成像和胞内微操作技术到脑片及活体成像。 我们的研究同时综合各类现代的细胞生物, 电生理, 和分子生物学技术来研究分子机制。

 PI 简历:
 郑强 (James Q Zheng)
 教授 (Tenured professor)
 细胞生物系 (Cell Biology) 和 神经系 (Neurology)
 Emory University School of Medicine

 清华大学物理学士,清华大学生物科学与技术系首位博士学位 (Ph.D.),美国哥伦比亚大学博士后

 1996年 - 任美国新泽西州立医科大学 (University of Medicine and Dentistry of New Jersey) 的罗伯特•伍德•强生医学院 (Robert Wood Johnson Medical School, 原为新州Rutgers州立大学医学院) 神经细胞生物系的助理教授 (tenure-track assistant professor). 2002年- 副教授并获终生教职 (Associate Professor with tenure). 2007年 - 正教授。兼任新州州立Rutgers大学教授成员, 参加Rutgers-UMDNJ两大州立大学 的联合研究生培养 (Joint graduate programs: Molecular BioScience 和 Neuroscience).
2008年- 美国南方私立大学Emory University (埃默里大学)的医学院 细胞生物系做终身教授. 同时在神经医学系兼任教授。并任Emory大学的神经退行性病变研究中心(Center for Neurogenerative Disease)的成员. 现任发育生物学和神经科学研究生培养计划的博士生导师。

其他荣誉: 2000-2008期间兼清华大学生物系神经生物研究所客座教授. 2005-2007年担任北美华人生物科学家协会神经科学分会的财务秘书(treasurer)。1991至1998年, 还在美国著名的海洋生物研究所(Marine Biological Laboratory, Woods Hole, MA)每年从事暑期科研. 曾获1995年史蒂芬•库富勒 伙伴(Stephen W. Kuffler fellow) 暑期科研奖 和1998年著名的尼康伙伴(Nikon fellow) 暑期科研奖. 现是美国神经科学学会和细胞生物学会的成员.

ABOUT THE PRINCIPAL INVESTIGATOR ...

Name:  James Q. Zheng
Title:    Professor
Education:   BS in Physics and Ph.D. in Biophysics , Tsinghua University; Postdoctoral training in Developmental Neurobiology, Columbia University.

Faculty Appointments:
1996: Assistant Professor, Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ.    2002: Associate Professor, Dept. of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ.    2007: Professor, Dept. of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ.    2008: Professor, Dept. of Cell Biology, Emory University, School of Medicine, Atlanta, GA.

A faculty member of Emory:  Neuroscience Program and The Biochemistry, Cell & Developmental Biology (BCDB) Program.

A regular member of  American Society of Cell Biologyand Society of Neuroscience.

 

Honors and Awards:

Guest Professor (2000-2008), Institute of Neuroscience, School of Life Science, Tsinghua University, Beijing, China;

Session Chair of “Axon guidance mechanisms and pathways II”,29th Annual Meeting (1999), Society for Neuroscience, Miami, FL;

Nikon fellow (1998), Marine Biological Laboratory, Woods Hole, MA;

  Nikon Instruments MBL Fellows list
Year Name Institution
1990 Tim Mitchison Harvard Medical School
1991 Ron Vale University of California, San Francisco
1991 Stephen Smith Stanford
1992 Andreas Stemmer Swiss Federal Institute of Technology, Zurich
1993 Vladimir Gelfand Northwestern University
1994 Andrew Murray Harvard University
1995 John Murray University of Pennsylvania, School of Medicine
1996 Jeff Lichtman Harvard University
1997 Gregg Gundersen Columbia University
1998 James Q. Zheng Emory University
1999 Edward Salmon The University of North Carolina at Chapel Hill
2000 Peter Saggau Baylor College of Medicine
2001 Fred Chang Columbia University Medical Center
2002 Jan Ellenberg European Molecular Biology Lab, Heidelberg Germany
2003 Alexey Khodjakov Wadsworth Center, NYS Department of Health
2004 Matthew Larkum University of Bern, Switzerland
2005 Jason Swedlow University of Dundee (UK)
2006 Jonathon Pines University of Cambridge (UK), Gurdon Institute
2007 Kerry Bloom The University of North Carolina at Chapel Hill
2008 Gaudenz Danuser Harvard Medical School
2009 Steano Tiozzo University of California, Santa Barbara
2010 Paul Selvin University of Illinois at Urbana-Champaign

Stephen W. Kuffler fellow (1995), Marine Biological Laboratory, Woods Hole, MA.

James' photos from 1996 to 2018

ABOUT OUR SCHOOL ...

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