1.  Behnke JA, Ye C, Moberg KH, and Zheng JQ (2021).  A protocol to detect neurodegeneration in Drosophila melanogaster whole-brain mounts using advanced microscopy    STAR Protocols   DOI: 10.1038/s41598-021-89121-7. PMID: ####.
        PMC free access  
  2.  Behnke JA, Ye C, Setty A, Moberg KH, and Zheng JQ (2021).  Repetitive Mild Head Trauma Induces Activity Mediated Lifelong Brain Deficits in a Novel Drosophila Model    Scientific Reports   11, 9738. doi: 10.1038/s41598-021-89121-7. PMID: 33958652.
        PMC free access  
  3.  Pollitt SL, Myers KR, Yoo J, and Zheng JQ (2020).  LIM and SH3 Protein 1 Localizes to the Leading Edge of Protruding Lamellipodia and Regulates Axon Development    Molecular Biology of the Cell;  2020 Nov 15;31(24):2718-2732. Epub 2020 Sept 30. doi: 10.1091/mbc.E20-06-0366. PMID: 32997597. A Highlights from MBoC Selection.
        PMC free access  
  4.  Rui Y, Pollitt SL, Myers KR, Feng Y, and Zheng JQ (2020).  Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca2+ Entry and Release.   eNeuro;  2020 Aug 17;7(4):ENEURO.0347-19.2020. PMID: 32409508 DOI:
             PMC free access  
  5.  Myers KR, Yu K, Kremerskothen J, Butt E, and Zheng JQ (2020).  The Nebulin Family LIM and SH3 Proteins Regulate Postsynaptic Development and Function.    The Journal of Neuroscience;  Jan 15;40(3):526-541; Epub 2019 Nov 21. PMID: 31754010. DOI:

    In This Issue  Higlighted in This Week in The Journal of Neuroscience

        PMC free access  
  6.  Omotade OF, Rui Y, Lei W, Yu K, Hartzell HC, Fowler VM, and Zheng JQ (2018).  Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation    The Journal of Neuroscience;  Nov 28;38(48):10271-10285; DOI:

    In This Issue  Higlighted in This Week in The Journal of Neuroscience

             PMC free access  
  7.  York AL and Zheng JQ (2017).  Super-Resolution Microscopy Reveals a Nanoscale Organization of Acetylcholine Receptors for Trans-Synaptic Alignment at Neuromuscular Synapses    eNeuro   Aug 10;4(4). pii: ENEURO.0232-17.2017. doi: 10.1523/ENEURO.0232-17.2017.
             PMC free access  

  1.  Bienkowski RS, Banerjee A, Rounds JC, Rha J, Omotade OF, Gross C, Morris KJ, Leung SW, Pak C, Jones SK, Santoro MR, Warren ST, Zheng JQ, Bassell GJ, Corbett AH, Moberg KH (2017).  The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons.    Cell Reports   Aug 8;20(6):1372-1384. doi: 10.1016/j.celrep.2017.07.038.
             PMC free access  
  2.  Lei W, Myers KR, Rui Y, Hladyshau S,Tsygankov D, and Zheng JQ (2017).  Phosphoinositide-Dependent Enrichment of Actin Monomers in Dendritic Spines Regulates Synape Develolpment and Plasticity    Journal of Cell Biology   216(8):2551-2564. doi: 10.1083/jcb.201612042. Epub 2017 Jun 28.
             PMC free access  
  3.  Omotade OF, Pollitt SL, and Zheng JQ (2017).  Actin-based growth cone motility and guidance.    Molecular and Cellular Neuroscience   Mar 6 2017. pii: S1044-7431(16)30261-5. doi: 10.1016/j.mcn.2017.03.001.
             PMC free access  
  4.  Li W, Allen ME, Rui Y, Ku L, Liu G, Bankston AN, Zheng JQ, Feng Y (2016).  p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.    Journal of Neuroscience   36(44):11283-11294.
             PMC free access  
  5.  Rui Y and Zheng JQ (2016).  Amyloid ▀ oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner.    Molecular Brain   9(1):79. doi: 10.1186/s13041-016-0261-z.
             PMC free access  
  6.  Lei W, Myers KR, and Zheng JQ (2016).  Actin cytoskeleton in dendritic spine development and plasticity.    Current Opinions in Neurobiology   39:86-92. doi: 10.1016/j.conb.2016.04.010.
             PMC free access  
  7.  Myers KR, Liu G, Feng Y, and Zheng JQ (2016).  Oligodendroglial defects during quakingviable cerebellar development.    Developmental Neurobiology   76(9):972-82. doi: 10.1002/dneu.22369.
             PMC free access  

  1.  Vitriol EA, McMillen LM, Kapustina M, Gomez SM, Vavylonis D, and Zheng JQ (2015).  Two functionally distinct sources of actin monomers supply the leading edge of lamellipodia.    Cell Reports   11(3):433-45. doi: 10.1016/j.celrep.2015.03.033.
             PMC free access  
  2.  Vitriol EA, McMillen LM, Kapustina M, Gomez SM, Vavylonis D, and Zheng JQ (2015).  Two functionally distinct sources of actin monomers supply the leading edge of lamellipodia.    Cell Reports   11(3):433-45. doi: 10.1016/j.celrep.2015.03.033.
             PMC free access  
  3.  Shim S, Zheng JQ, and Ming GL (2013).  A Critical Role for STIM1 in Filopodial Calcium Entry and Axon Guidance    Molecular Brain   6:51 (December 1, 2013). DOI: 10.1186/10.1186/1756-6606-6-51.
             PMC free access  
  4.  Rui Y, Myers KR, YU K, Wise AL, De Blas A, Hartzell HC, and Zheng JQ (2013).  Activity-dependent Regulation of Dendritic Growth and Maintenance by Glycogen Synthas Kinase 3▀"    Nature Communications   4:2628 (Oct 29). doi: 10.1038/ncomms3628.
        PMC free access  
  5.   Vitriol EA, Wise AL, Berginski ME, Bamburg JR, and Zheng JQ (2013).  Instantaneous Inactivation of Cofilin Reveals Its Function of F-actin Disassembly in Lamellipodia.    Molecular Biology of the Cell   24:14 2238-2247. May 15 - epub ahead of print.
    Access the recommendation on F1000Prime
                   Suppl material  
                  Suppl movie#1  
                  Suppl movie#2  
        PMC free access          Suppl movie#3  
  6.  Lee CW*, Vitriol EA*, Shim S, Wise AL, Velayutham RP, and Zheng JQ (2013).  Dynamic Localization of G-actin During Membrane Protrusion in Neuronal Motility.    Current Biology   23(12): 1046-1056.
        PMC free access  
  7.  Vitriol EA and Zheng JQ (2012).  Growth Cone Travel in Space and Time: the Cellular Ensemble of Cytoskeleton, Adhesion, and Membrane.    Neuron, the Cell Press  73(6):1068-1081.  
             PMC free access   
  8.  Han L, Wen Z, Lynn RC, Baudet M-L, Holt CE, Sasaki Y, Bassell GJ, and Zheng JQ (2011).   Regulation of Chemotropic Guidance of Nerve Growth Cones by microRNA.   Molecular Brain  4:40.
             PMC free access   
  9.  Fan Y, Tang X, Vitriol E, Chen G, and Zheng JQ (2011).   Actin Capping Protein is Required for Dendritic Spine Development and Synapse Formation   Journal of Neuroscience  31(28):10228-10233.
        PMC free access  
  10.   Sweet ES, Previtera ML, Fernßndez JR, Charych EI, Tseng C-Y , Kwon M, Starovoytov V, Zheng JQ, and Firestein BL (2011).  PSD-95 Alters Microtubule Dynamics via an Association With EB3.   Journal of Neuroscience  31(3): 1038-1047.
             PMC free access

  1.   Gu J*, Lee CW*, Fan Y*, Komlos D, Tang X, Sun C, Yu K, Hartzell1 HC, Chen G, Bamburg JR, and Zheng JQ (2010).   ADF/Cofilin-Mediated Actin Dynamics Regulate AMPA Receptor Trafficking during Synaptic Plasticity.   Nature Neuroscience  13(10):1208ľ1215.  
             PMC free access    supplemental data
  2.    Lau A, Irier H, Gu J, Tian D, Ku L, Liu G, Xia M, Fritsch B, Zheng JQ, Dingledine R, Xu B, Lu B, Feng Y (2010).   Distinct 3'UTRs differentially regulate activity-dependent translation of BDNF.   Proceedings of the National Academy of Sciences  107(36):15945-15950.  
             PMC free access   
  3.    Sasaki Y, Welshhans K, Wen Z, Yao Y, Xu M, Goshima Y, Zheng JQ, and Bassell GJ (2010).   Phosphorylation of zipcode binding protein is required for BDNF signaling of local beta-actin synthesis and growth cone turning   Journal of Neuroscience  30(28):9349-9358.  
             PMC free access   
  4.  Rui Y, Gu J, Yu K, Hartzell HC and Zheng JQ (2010).   Inhibition of AMPA Receptor Trafficking at Hippocampal Synapses by ▀-amyloid Oligomers: the Mitochondrial Contribution.   Molecular Brain  3:10.  
             PMC free access   
  5.  Gu J and Zheng JQ (2009).   Microtubules in Dendritic Spine Development and Plasticity.  The Open Neuroscience Journal  3:128-133 (peer-reviewed minireview article in the special volume: Hot Topic:Exciting Dendritic Spines).  
             PMC free access   
  6.  Lee CW, Han J, Bamburg JR, Han L, Lynn R, and Zheng JQ (2009).   Regulation of Acetylcholine Receptor Clustering by ADF/Cofilin-Directed Vesicular Trafficking.  Nature Neuroscience  12:848 - 856.  
             PMC free access    supplemental data
  7.  Gu J, Firestein BL, and Zheng JQ (2008).  Microtubules in Dendritic Spine Development.  Journal of Neuroscience  28(46):12120-12124.  
               PMC free access
  8.  Zheng JQ and Poo MM (2007).  Calcium Signaling in Neuronal Motility.  Annual Review of Cell and Developmental Biology  Vol.23: 375-404 (Nov).
  9.  Wen Z*, Han L*, Bamburg JR, Shim S, Ming GL, and Zheng JQ (2007).  BMP Gradients Steer Nerve Growth Cones by a Balancing Act of LIM Kinase and Slingshot Phosphatase on ADF/Cofilin.  Journal of Cell Biology  178(1):107-119.  
        PMC free access       supplemental data  
        SCIENCE STKE Editor's Choice. Science STKE, tw241 (2007).
  10.  Alder J and Zheng JQ (2007).  Surfing on Calcium Waves.  Neuron, the Cell
Press 54(4): 502-505.
  11.  Han J, Han L, Tiwari P, Wen Z, and Zheng JQ (2007).  Spatial Targeting of Type II Protein Kinase A to Filopodia Mediates the Regulation of Growth Cone Guidance by cAMP.  Journal of Cell Biology  176(1): 101-111.
    JCB Cover!
        PMC free access       In This Issue   
            featured on the cover of this JCB issue.
  12.  Rui Y, Tiwari P, Xie ZP, and Zheng JQ (2006).  Acute Impairment of Mitochondrial Trafficking by ▀-amyloid Peptides in Hippocampal Neurons.  Journal of Neuroscience  26(41):10480-10487.
  13.  Charych EI, Akum BF, Goldberg JS, J÷rnsten RJ, Rongo C, Zheng JQ, and Firestein BL (2006).  Activity-Independent Regulation of Dendrite Patterning by Postsynaptic Density Protein PSD-95.  Journal of Neuroscience  26(40): 10164-10176.
     Visit Firestein Lab.
  14.  Yao J, Sasaki Y, Bassell G, and Zheng JQ (2006).  An Essential Role for ▀-actin mRNA Localization and Translation in Ca2+-dependent Growth Cone Guidance.  Nature Neuroscience  9(10): 1265-1273. Published online Sept.17, 2006.  
            News & Views    

    SCIENCE STKE Editor's Choice. E.M. Adler, Translating Cues into Action, Science STKE, tw339 (2006).

    Nature Signaling Gateway.  Axon guidance: The asymmetry of attraction.   October featured articles.

  15.  Gomez TM and Zheng JQ (2006).  Molecular Basis for Calcium-Dependent Axon Pathfinding.  Nature Review Neuroscience  7(2):115-125 (featured review article, peer reviewed).
  16.  Wen Z and Zheng JQ (2006).  Directional Guidance of Nerve Growth Cones.  Current Opinion in Neurobiology   16(1):52-58.
  17.  Guirland C and Zheng JQ (2005). Lipid Rafts and Their Role in Axon Guidance,  in Axon Growth and Guidance (ed. Dominique Bagnard). Landes Bioscience. In Press

  18. Read the chapter at PubMed Bookshelf.    

  19.  Wen Z, Guirland C, Ming G-L, and Zheng JQ (2004).    A CaMKII/Calcineurin Switch Controls the Direction of Ca2+-dependent Growth Cone Guidance.  Neuron, the Cell 
Press 43(6):835-846.  
    NEURON Preview            
  20.  Guirland C, Suzuki S, Kojima M, Lu B, and Zheng JQ (2004).    Lipid Rafts Mediate Chemotropic Guidance of Nerve Growth Cones.  Neuron, the Cell 
Press 42(1):51-62.  
    NEURON Preview            
  21.  Spikes in color!Liu ZJ*, Geng L*, Li RX, He XP, Zheng JQ, and Xie ZP (2003).   Frequency Modulation of Synchronized Ca2+ Spikes in Cultured Hippocampal Networks Through G Protein-Coupled Receptors.   Journal of Neuroscience  23(10):4156-4163.   This work was performed in Tsinghua University, Beijing, China.   JQZ and ZPX are co-corresponding authors.
  22.  Guirland C*, Buck KB*, Gibney JA, Dicicco-Bloom E, and Zheng JQ (2003).   Direct cAMP Signaling Through G Protein-Coupled Receptors Mediates Growth Cone Attraction Induced by Pituitary Adenylate Cyclase-Activating Polypeptide.   Journal of Neuroscience  23(6):2274-2283.  
  23.  Gibney JA and Zheng JQ (2003).   Cytoskeletal Dynamics Underlying Collateral Membrane Protrusions Induced by Neurotrophins in Cultured Xenopus Spinal Neurons.  Journal of Neurobiology  54(2):393-405.
    Journal cover of the issue!        
  24.  Buck KB and Zheng JQ (2002).    Growth Cone Turning Induced by Direct Local Modification of Microtubule Dynamics.  Journal of Neuroscience  22(21):9358-9367.  
    Supplementary video clips (Microsoft avi files):
    20 nM Cytochalasin D inhibted growth cone motility
    100 pg/ml Toxin B did not affect growth cone motility
    Both drugs, however, effectively blocked the attractive and repulsive turning of growth cones induced by different cues.   For details, please see the article.
  25.  Zheng JQ (2000).   Turning of Nerve Growth Cones Induced by Localized Increases in Intracellular Calcium Ions. Nature
Magzine 403:89-93 (Jan. 6).

  26.  DiCicco-Bloom E, Deutsch PJ, Maltzman J, Zhang JW, Pintar JE, Zheng JQ, Friedman WF, and Zaremba T (2000): Autocrine Expression and Ontogenetic Functions of the PACAP Ligand/Receptor System during Sympathetic Development.   Developmental Biology  219:197-213.
  27.  Wang Q. and Zheng JQ (1998).  cAMP-Mediated Regulation of Neurotrophin-Induced Collapse of Nerve Growth Cones.  Journal of Neuroscience  18(13):4973-4984.
  28.  Ming GL, Lohof AM,and Zheng JQ (1997):  Acute Morphogenic and Chemotropic Effects of Neurotrophins on Cultured Embryonic Xenopus Spinal Neurons.   Journal of Neuroscience  17(20):7860-7871.
  29.  Zheng JQ , Poo MM, and Connor JA (1996). Calcium and chemotropic turning of nerve growth cones.  Perspectives on Developmental Neurobiology  4(2/3):205. Review article, click here to request a reprint with color figures.
  30.   Zheng JQ, Wan, JJ, and Poo MM (1996):  Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient.   Journal of Neuroscience  16, 1140-1149.
    Journal cover of the issue! Read the abstract online or request a reprint from us.   Our color image of growth cone turning in a chemical gradient was featured on the cover of this issue. Click here to view the picture used for the cover.
  31.  Wang XH, Zheng JQ, Poo MM (1996). Effects of cytochalasin treatment on short-term synaptic plasticity at developing neuromuscular junctions in frogs.  Journal of Physiology  491, 187-195.
  32.  Girod R, Popov SV, Alder JE, Zheng JQ, Lohof AM, and Poo MM (1995): Spontaneous quantal transmitter secretion from myocytes and fibroblasts: comparison with neuronal secretion.   Journal of Neuroscience  15(4): 2826-2838.
  33.  Zheng JQ, Felder M, Connor JA, and Poo MM (1994): Turning of nerve growth cones induced by neurotransmitters. Nature Magzine 368, 140-144 (Click here to view a pseudocolor Ca2+ imaging sequence showing the rise of Ca2+ at the growth cone upon transmitter application).  
  34.  Zheng JQ, Zheng ZW, and Poo MM (1994): Long-range signaling in growing neurons after local elevation of cAMP activity.   Journal of Cell Biology  127, 1693-1701.  
    Journal cover of the issue! (Click here to view the picture used for the cover of this issue of JCB). You can download the PDF file from the JCB website

 Our favorite.

* These authors contributed equally to the work.

About the laboratory of Dr. James Zheng Meet the people Learn about the research Check out our publications Resources and Links Positions available Visit our media gallery Back to the Lab Home Emory Cell Biology Emory University Emory University