Name: Andrew Patrick Kowalczyk, Ph.D. Title: Associate Professor Cell Biology Email: email@example.com Phone: 4047273076
Address:Whitehead Biomedical Research Building Room 405M , 615 Michael Street , Atlanta , GA , 30322
Molecular interactions, assembly, and signaling of adhesive intercellular junctions in development and disease.
The main focus of the laboratory is to reveal mechanisms of adhesion between keratinocytes and vascular endothelial cells in the context of skin biology. Specifically, we are investigating the functions and regulation of the cadherin family of adhesion molecules. These molecules mediate homophilic interactions and play key roles in the patterning of tissues during development and in the maintenance of tissue architecture in adults. A major focus of our studies is to understand how cadherins are modulated by endocytic membrane trafficking pathways, and how the dynamic presentation of adhesion molecules at the plasma membrane is regulated during development and disease.
33. Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Reynolds AB, Kowalczyk AP (2010): p120-catenin is required for mouse vascular development. Circ. Res. In:Press
32. Chiasson CM, Wittich KB, Vincent PA, Faundez V, Kowalczyk AP (2009): p120 Catenin inhibits VE-cadherin internalization through a rho-independent mechanism.. Mol. Biol. Cell 20:1970-1980
27. Delva E, Jennings JM, Calkins CC, Kottke MD, Faundez V, Kowalczyk AP. (2008): Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin and dynamin-independent mechanism.. J Biol Chem 283:18303-1831