Publications

Recent and previous key publications in the different projects:

1. Developmental specification and network integration of V1 inhibitory interneurons in spinal motor circuits.

Original Articles

Bikoff JB, Gabitto MI, Rivard AF, Drobac E, Machado TA, Miri A, Brenner-Morton S, Famojure E, Diaz, C, Alvarez FJ, Mentis GZ, Jessell TM (2016) Spinal inhibitory interneuron diversity defines variant motor microcircuits. Cell 165(1):207-219.
https://doi-org.proxy.library.emory.edu/10.1016/j.cell.2016.01.027

Siembab VC, Gomez-Perez, L, Rotterman TM, Shneider NA, Alvarez FJ (2016) Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells. J. Comp. Neurol. 524(9):1892-1919.
https://doi-org.proxy.library.emory.edu/10.1002/cne.23946

Zhang J, Lanuza GM, Wang Z, Siembab VC, Zhang Y, Velasquez T, Alvarez FJ, Frank E, Goulding M (2014) V1 and V2b interneurons generate the alternating flexor-extensor motor activity vertebrates use for locomotion and protective reflexes. Neuron 82(1):138-150.
https://doi-org.proxy.library.emory.edu/10.1016/j.neuron.2014.02.013

Benito-Gonzalez A, Alvarez FJ (2012) Renshaw cells and Ia inhibitory interneurons are generated at different times from p1 progenitors and differentiate shortly after exiting the cell cycle. J. Neurosci. 32(4): 1156-1170. 
https://doi-org.proxy.library.emory.edu/10.1523/JNEUROSCI.3630-12.2012

Alvarez FJ, Jonas P, Sapir T. Hartley R, Geiman EJ, Todd A, Goulding, M (2005) Postnatal phenotype and localization of spinal cord V1 derived interneurons. J. Comp. Neurol. 493: 177-192. 
https://doi-org.proxy.library.emory.edu/10.1002/cne.20711

Sapir T, Geiman EJ, Wang Z, Velasquez T, Frank E, Alvarez FJ, Goulding M (2004) Pax6 and En1 Regulate Two Critical Aspects of Renshaw Cell Development. J. Neurosci. 24: 1255-1264. 
https://doi-org.proxy.library.emory.edu/10.1523/JNEUROSCI.3187-03.2004

Invited Prespectives

Alvarez FJ (2018) Spinal Interneurons "a La Carte". Neuron 100:3-6.
https://doi-org.proxy.library.emory.edu/10.1016/j.neuron.2018.09.034 

Reviews

Alvarez FJ, Benito-Gonzalez A, Siembab VC (2013) Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit. Ann NY AcadSciences 1279(1):22-31.
https://doi-org.proxy.library.emory.edu/10.1111/nyas.12084

Alvarez FJ, Fyffe REW (2007) The continuing case for the Renshaw cell. J. Physiol. 584: 31-45.
https://doi-org.proxy.library.emory.edu/10.1113/jphysiol.2007.136200

 

Recent Abstracts 

Lane AR, Alvarez FJ (2019) Development of a dual-conditional transgenic mouse model for genetic targeting of Renshaw cells in adult animals. Society for Neuroscience. Chicago, Illinois, November 2019.

Mistretta OC, Worthy AE, Greenfiled NM, Bikoff JB, English AW, Alvarez FJ (2021) Loss of Foxp2-V1 interneurons results in hyper flexion and limb discoordination during locomotion. Society for Neuroscience. Chicago, Illinois, November 2021.

Bichler, EK, Rivard AF, Alvarez FJ (2021) V1 interneuron expressing the Mafb transcription factor include Renshaw Cells and display bursting firing phenotypes and unique properties. Society for Neuroscience. Chicago, Illinois, November 2021.

2. Circuit modifications after peripheral nerve injuries and neuroinflammation.

Original Articles

Rotterman TM, Alvarez FJ (2020) Microglia dynamics and interactions with motoneurons axotomized after nerve injuries revealed by two-photon microscopy. Sci. Rep. 10:8648
https://doi.org/10.1038/s41598-020-65363-9        use link: https://rdcu.be/b4pQA 

Rotterman TM, Akhter ET, Lane AR, MacPherson KP, García VV, Tansey MG, Alvarez FJ (2019) Spinal motor circuit synaptic plasticity after peripheral nerve injury depends on microglia activation and a CCR2 mechanism. J. Neurosci 39(18):3412-3433. 
https://www-jneurosci-org.proxy.library.emory.edu/content/39/18/3412.long 

Schultz AJ. Rotterman TM, Dwarakanath A, Alvarez FJ (2017) VGLUT1 synapses and P-boutons on regenerating motoneurons after nerve crush. J. Comp. Neurol. 525(13):2876-2889.
https://doi-org.proxy.library.emory.edu/10.1002/cne.24244  

Rotterman TM, Nardelli P, Cope TC, Alvarez FJ (2014) Normal distribution of VGLUT1 synapses on spinal motoneuron dendrites and their reorganization after nerve injury. J. Neurosci. 34:3475-3492.
https://doi-org.proxy.library.emory.edu/10.1523/JNEUROSCI.4768-13.2014

Alvarez FJ, Titus HE, Bullinger KL, Kraszpulski M, Nardelli P, Cope TC (2011) Permanent central synaptic disconnection of proprioceptors  after nerve injury and regeneration: I. Loss of VGLUT1/IA synapses on motoneurons. J. Neurophysiol. 106(5): 2450-2470
https://doi-org.proxy.library.emory.edu/10.1152/jn.01095.2010

Bullinger KL, Nardelli P, Alvarez FJ, Cope TC (2011) Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration: II. Loss of functional connectivity with motoneurons. J. Neurophysiol. 106(5): 2471-2485
https://doi-org.proxy.library.emory.edu/10.1152/jn.01097.2010

Reviews

Alvarez FJ,Rotterman TM, Akhter ET, Lane AR, Englihs AW, Cope TC (2020) Synaptic plasticity on motoneurons after axotomy: A necessary change in paradigm. Front Mol Neurosci 13:68
https://doi: 10.3389/fnmol.2020.00068  

Alvarez FJ, Bullinger K, Titus HE, Nardelli, P, Cope TC (2010) Central structural reorganization of Ia afferent synapses after peripheral nerve injuries. Ann NY AcadSciences 1198: 231- 241
https://doi-org.proxy.library.emory.edu/10.1111/j.1749-6632.2010.05459.x

Recent Abstracts

Rotterman TM, Nardelli P, Garcia VV, Alvarez FJ, Cope TC (2019) Preservation of Ia afferent synaptic inputs on regenerated motoneurons after nerve injury partially restores function. Society for Neuroscience. Chicago, Illinois, November 2019.

3. Mechanisms regulating KCC2 expression in axotomized motoneurons and its role in motor axon regeneration.

Publications

Akhter ET, Griffith RW, English AW, Alvarez FJ (2019) Removal of the potassium chloride co-transporter from the somatodendritic membrane of axotomized motoneurons is independent of BDNF/TrkB signaling but is controlled by neuromuscular innervation. eNeuro. 16;6(5).
https://doi.org/10.1523/ENEURO.0172-19.2019 

Reviews

Akhter ET, English AW, Alvarez FJ (2020) Chapter 19: "Neuronal Chloride Homeostasis and nerve injury" in Neuronal Chloride Transporters in Health and Disease. Pages 517-547. Edited by Xin Tang (MIT). Elsevier, Academic Press. ISBN  978-0-12-815318-5
https://doi.org/10.1016/C2017-0-02771-4

Recent Abstracts 

Akhter ET, Sarin S, English AW, Alvarez FJ (2019) The potassium-chloride cotransporter KCC2 is regulated by muscle innervation, but not exercise, in spinal motoneurons following peripheral axotomy. Society for Neuroscience. Chicago, Illinois, November 2019.

4. Other publications in past five years.

Rotterman TM, Haley-Johnson Z, Pottorf TS, Chopra T, Chang E, Zhang S, McCallum WM, Fisher S, Franklin H, Alvarez M, Cope TC, Alvarez FJ (2024) Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.
Cell Rep. 43(2):113776
10.1016/j.celrep.2024.113776

Mistretta OC, Wood RL, English AW, Alvarez FJ (2024) Air-stepping in the neonatal mouse: a powerful tool for analyzing early stages of rhythmic limb movement development.
J Neurophysiol. 131(2):321-337.
https://journals.physiology.org/doi/abs/10.1152/jn.00227.2023

Alvarez FJ (2019) A motor physiology recurrent topic: Simplify assumptions to gain extra insight. J. Physiol. 597(8):2117-2118
https://physoc-onlinelibrary-wiley-com.proxy.library.emory.edu/doi/full/10.1113/JP277715 

Gregoriades J, Madaris A, Alvarez FJ, Alvarez-Leefmans FJ (2018) Genetic and pharmacologic inactivation of apical NKCC1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter.  American J. of Physiol. 316(4):C525-C544. 
https://doi-org.proxy.library.emory.edu/10.1152/ajpcell.00026.2018 

Alvarez FJ (2017) Gephyrin and the regulation of synaptic strength and dynamics at glycinergic inhibitory synapses. Brain Res. Bull. 129:506-http://doi.org.proxy.library.emory.edu/10.1016/j.brainresbull.2016.09.003

Dr. Francisco J. Alvarez complete bibliography

Dr. Alvarez's complete bibliography at NCBI.