People in the Bassell Lab
Gary J. Bassell, Ph.D. joined the faculty at Emory University School of Medicine in 2005, where he is currently Professor and Chair of the Department of Cell Biology http://cellbio.emory.edu. Prior to moving Emory, Dr. Bassell was a member of the faculty at the Albert Einstein College of Medicine, in the Department of Anatomy and Structural Biology (1995-1998) and subsequently in the Department of Neuroscience and Rose Kennedy Center for Mental Retardation (1998-2005). Read More
Anwesha Banerjee, PhD
My overall research focuses on understanding the central nervous system (CNS) associated molecular and behavioral pathology in repeat expansion disorders such as Myotonic Dystrophy Type 1 (DM1) and Fragile X syndrome. My current project involves using a novel AAV based mice model
Pernille (Penny) Buelow
Graduate Student (Ph.D. program, NS)
Graduate Student (Ph. D program, Neuroscience)
My research centers around elucidating the neural mechanisms underlying inhibitory brain circuits in the disease state, specifically by characterizing two different mouse models of Myotonic Dystrophy Type 1 (DM1). Enhancement of inhibitory pathways of the brain naturally lead to the familiar quiescent states of anesthesia and sleep; however in DM1 patients, these states are negatively altered with deleterious effects. DM1 is a neuromuscular, neurodegenerative, and multisystemic disease with many of its central nervous system symptoms, such as emergence and recovery from anesthesia and hypersomnia under-researched. My research in Dr. Bassell’s lab examines how sequestration of Muscle blind like protein 2 (MBNL2), an RNA-binding protein which loses its function in DM1, alters the expression of specific inhibitory receptors. These receptors play a role in delayed emergence and recovery from anesthesia and increased sleep phenotypes observed in DM1.
Graduate Student (PhD program, Biomedical Engineering)
I am currently investigating the interaction between Muscleblind-like (MBNL) RNA-binding protein and kinesin motor proteins and the role that this interaction plays in proper localization of mRNA in neurons. mRNA mislocalization due to MBNL nuclear sequestration is one of the major pathogenic contributors to myotonic dystrophy.
Graduate Student (Ph.D. program, NS)
My research is focused on the mechanism of the muscleblind-like (
Graduate Student (Ph.D. Biomedical Engineering, joint program with Georgia Tech)
My research is focused on understanding shared mechanisms between C9 ALS/FTD and
GiaLinh (Linda) Nguyen, MPH
Research Administrative Coordinator
As the Research Administrative Coordinator for the Bassell Lab, I ensure that the lab is in compliance with Emory’s research policies. My primary duties include overseeing daily lab activities, tracking laboratory expenditures, monitoring grant budgets, ordering laboratory consumables and chemical reagents, and maintaining laboratory records, biosafety manuals, chemical stock, and communal lab space in accordance with laboratory and biosafety regulations. I also assist the graduate students and research staff with various administrative tasks as needed.
Graduate Student (Ph.D. program)
My research is focused on examining how defects in mRNA processing and
localization contributes to the disease pathology of Spinal Muscular
Atrophy in vivo.
3q29 deletion is a recurrent copy number variant and is the highest known genetic risk factor for schizophrenia. However, the molecular basis for this risk has not been identified and is a major unanswered question. The goal of my research is to characterize the neuronal consequences of 3q29 deletion using both a mouse model and human cells. My primary focus is the generation of neurons from patient-derived induced pluripotent stem cells for morphological and signaling pathway analysis. These studies will help us to better understand the cellular and molecular consequences of this genetic variant and may also provide important insights into the molecular basis of schizophrenia.
Graduate Student (Ph.D. program, Neuroscience)
I am interested in studying the molecular mechanisms underlying specific cognitive, cellular and synaptic impairments seen in FXS, 15q13DS, DiGeorge syndrome and other
Graduate Student (MD/PhD program)
My research focuses on the physiologic regulation of the Fragile X Mental Retardation Protein's (FMRP) targeting of mRNAs and the RNA-induced silencing complex (RISC). Specifically, my current project is exploring the ubiquitination of FMRP following mGluR5 stimulation.