2017 Publications

Bienkowski RS, Banerjee A, Rounds JC, Rha J, Omotade OF, Gross C, Morris KJ, Leung SW, Pak C, Jones SK, Santoro MR, Warren ST, Zheng JQ, Bassell GJ, Corbett AH, Moberg KH. The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Cell Rep. 2017 Aug 8;20(6):1372-1384. doi: 10.1016/j.celrep.2017.07.038. [PMID: 28793261]

Thomas KT, Anderson BR, Shah N, Zimmer SE, Hawkins D, Valdez AN, Gu Q, Bassell GJ. Cell Rep. Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction. Cell Rep. 2017 Jul 5;20(1):1-12. [PMID: 28683304].

Rha J, Jones SK, Fidler J, Banerjee A, Leung SW, Morris KJ, Wong JC, Inglis GAS, Shapiro L, Deng Q, Cutler AA, Hanif AM, Pardue MT, Schaffer A, Seyfried NT, Moberg KH, Bassell GJ, Escayg A, García PS, Corbett AH. The RNA-binding Protein, ZC3H14, is Required for Proper Poly(A) Tail Length Control, Expression of Synaptic Proteins, and Brain Function in Mice. Hum Mol Genet. 2017 Jun 29. doi: 10.1093/hmg/ddx248. [Epub ahead of print] [PMID: 28666327]

McAninch DS, Heinaman AM, Lang CN, Moss KR, Bassell GJ, Rita Mihailescu M, Evans TL. Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR. Mol Biosyst. 2017 Jul 25;13(8):1448-1457. doi: 10.1039/c7mb00070g. PubMed PMID: 28612854; [PMCID: PMC5544254]

Urbanska AS, Janusz-Kaminska A, Switon K, Hawthorne AL, Perycz M, Urbanska M, Bassell GJ, Jaworski J. ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons. Sci Rep. 2017 May 12;7(1):1876. doi: 10.1038/s41598-017-01963-2. PubMed PMID: 28500298; [PMCID: PMC5431813]

Donlin-Asp PG, Rossoll W, Bassell GJ. Spatially and temporally regulating translation via mRNA-binding proteins in cellular and neuronal function. FEBS Lett. 2017 Jun;591(11):1508-1525. doi: 10.1002/1873-3468.12621. Epub 2017 Apr 3. Review. [PMID: 28295262]

Donlin-Asp PG, Fallini C, Campos J, Chou CC, Merritt ME, Phan HC, Bassell GJ, Rossoll W. The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly. Cell Rep. 2017 Feb 14;18(7):1660-1673. doi: 10.1016/j.celrep.2017.01.059. PubMed PMID: 28199839; [PMCID: PMC5492976]

Lepelletier L, Langlois SD, Kent CB, Welshhans K, Morin S, Bassell GJ, Yam PT, Charron F. Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation. J Neurosci. 2017 Feb 15;37(7):1685-1695. doi: 10.1523/JNEUROSCI.3016-16.2016. Epub 2017 Jan 10. [PMID: 28073938]

2016 Publications

2. Williams KR, McAninch DS, Stefanovic S, Xing L, Allen M, Li W, Feng Y, Mihailescu MR, Bassell GJ. hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation. Mol Biol Cell. 2016 Feb 1;27(3):518-34. [PMID: 26658614]

2015 Publications

3. Suhl JA, Muddashetty RS, Anderson BR, Ifrim MF, Visootsak J, Bassell GJ, Warren ST. A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR. Proc Natl Acad Sci U S A. 2015 Nov 9. [Epub ahead of print]

4. Stefanovic S, DeMarco BA, Underwood A, Williams KR, Bassell GJ, Mihailescu MR. Fragile X mental retardation protein interactions with a G quadruplex structure in the 3'-untranslated region of NR2B mRNA.
Mol Biosyst. 2015 Sep 28. [Epub ahead of print] PMID:26412477

5. Richter JD, Bassell GJ, Klann E. Dysregulation and restoration of translational homeostasis in fragile X syndrome. Nat Rev Neurosci. 2015 Oct;16(10):595-605. Epub 2015 Sep 9

6 Gross C, Hoffmann A, Bassell GJ, Berry-Kravis EM. Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back. Neurotherapeutics. 2015
Jul;12(3):584-608. PMID: 25986746; PMCID: PMC4489963.

7. Gross C, Chang CW, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell Rep. 2015 May 5;11(5):727-36. Epub 2015 Apr 23. [PMID: 25921541]

8. Ifrim MF, Williams KR, Bassell GJ. Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. Single-Molecule Imaging of PSD-95 mRNAJ Neurosci. 2015 May 6;35(18):7116-30. PMID: 25948262; PMCID: PMC4420780.

9. Gross C, Raj N, Molinaro G, Allen AG, Whyte AJ, Gibson JR, Huber KM, Gourley SL, Bassell GJ. Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome. Cell Rep. 2015 May 5;11(5):681-8. Epub 2015 Apr 23. [PMID: 25921527]

10. Zhang Y, Gaetano CM, Williams KR, Bassell GJ, Mihailescu MR. FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA. RNA Biol. 2014;11(11):1364-74. [PMID: 25692235]

2014 Publications

12. Fallini C, Rouanet JP, Donlin-Asp PG, Guo P, Zhang H, Singer RH, Rossoll W, Bassell GJ. Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons. Dev Neurobiol. 2014 Mar;74(3):319-32. Epub 2013 Oct 4. PMID: 23897586; PMCID: PMC3906212.

13. Sasaki Y, Gross C, Xing L, Goshima Y, Bassell GJ. Identification of axon-enriched microRNAs localized to growth cones of cortical neurons. Dev Neurobiol. 2014 Mar;74(3):397-406. Epub 2013 Sep 13. Erratum in: Dev Neurobiol. 2014 Apr;74(4):481. PMID: 23897634; PMCID: PMC4111797.

14. Wigington CP, Williams KR, Meers MP, Bassell GJ, Corbett AH. Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions. Wiley Interdiscip Rev RNA. 2014 Sep-Oct;5(5):601-22. Epub 2014 Apr 30. Review.  PMID: 24789627; PMCID: PMC4332543.

15. Gross C, Bassell GJ. Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders. Front Mol Neurosci. 2014 Feb 13;7:12. eCollection 2014. Review. PMID: 24592210;   PMCID: PMC3923137.

16. Suhl JA, Chopra P, Anderson BR, Bassell GJ, Warren ST. Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences. Hum Mol Genet. 2014 Oct 15;23(20):5479-91. Epub 2014 May 29. PMID: 24876161; PMCID: PMC4168832.

17. Zhang Y, Gaetano CM, Williams KR, Bassell GJ, Mihailescu MR. FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA. RNA Biol. 2014;11(11):1364-74. PMID: 25692235; PMCID: PMC4615183.

2013 Publications

18. Larimore J, Ryder PV, Kim KY, Ambrose LA, Chapleau C, Calfa G, Gross C, Bassell GJ, Pozzo-Miller L, Smith Y, Talbot K, Park IH, Faundez V. MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.  PLoS One. 2013 Jun 4;8(6):e65069. doi: 10.1371/journal.pone.0065069. Print 2013. PMID:23750231 Free PMC Article

19. Swanger SA, He YA, Richter JD, Bassell GJ. Dendritic GluN2A synthesis mediates activity-induced NMDA receptor insertion. J Neurosci. 2013 May 15;33(20):8898-908. PMID: 23678131; PMCID: PMC3684268.

20. Swanger SA, Bassell GJ. Dendritic protein synthesis in the normal and diseased brain. Neuroscience. 2013 Mar 1;232:106-27. Epub 2012 Dec 20. Review. PMID:
23262237; PMCID: PMC4502914.

21. Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD. Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nat Med. 2013 Nov;19(11):1473-7. Epub 2013 Oct 20. PMID: 24141422; PMCID: PMC3823751.

22. Xing L, Bassell GJ. mRNA localization: an orchestration of assembly, traffic and synthesis. Traffic. 2013 Jan;14(1):2-14. Epub 2012 Sep 13. Review. PMID: 22913533;   PMCID: PMC3548013.

2012 Publications

23. Xing L, and Bassell GJmRNA localization: an orchestration of assembly, traffic and synthesis. Traffic. 2012; Aug 22. PMID: 22913533.

24. Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu ZS, van den Berg LH, Glass JD, Siciliano G, Cirulli ET, Goldstein DB, Salachas F, Meininger V, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ,  Silani V, Drory VE, Brown RH, Landers JE. Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature. 2012; Jul 15. PMID: 22801503

25. Emory News

26. Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ,  and Seyfried NT. Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination. PLoS One. 2012; Jun 21. PMID: 22761693

27. Udagawa T, Swanger SA, Takeuchi K, Kim JH, Nalavadi V, Shin J, Lorenz LJ, Zukin RS, Bassell GJ, and Richter JD. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.Mol Cell. 2012; Jul 27 PubMed

28. Fallini C, Bassell GJ,  and Rossoll W. The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth. Hum Mol Genet. 2012; Aug 15 PubMed

HHM Cover

29. EMORY Health Now Blog

30. Ceci M, Welshhans K, Ciotti MT, Brandi R, Parisi C, Paoletti F, Pistillo L, Bassell GJ,  and Cattaneo A. RACK1 is a ribosome scaffold protein for β-actin mRNA/ZBP1 complex. PLoS One. 2012; Apr 16 PubMed

31. Wilhelm JC, Xu M, Cucoranu D, Chmielewski S, Holmes T, Lau KS, Bassell GJ,  and English AW. Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. J Neurosci. 2012; Apr 4 PubMed

32. Nalavadi VC, Muddashetty RS, Gross C, and Bassell GJ.  Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation. J Neurosci. 2012; Feb 22 PubMed

33. Xing L, Yao X, Williams KR, and Bassell GJ.  Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Mol Biol Cell. 2012; Feb 29 PubMed

34. Fallini C, Bassell GJ, and Rossoll W. Spinal muscular atrophy: The role of SMN in axonal mRNA regulation. Brain Res 2012; Jan 28. PMCID: 22330725