People in the Bassell Lab
Gary J. Bassell, PhD
Professor and Chair, Department of Cell Biology
gbassel@emory.edu
Gary J. Bassell, Ph.D. joined the faculty at Emory University School of Medicine in 2005, where he is currently Professor and Chair of the Department of Cell Biology http://cellbio.emory.edu. Prior to moving Emory, Dr. Bassell was a member of the faculty at the Albert Einstein College of Medicine, in the Department of Anatomy and Structural Biology (1995-1998) and subsequently in the Department of Neuroscience and Rose Kennedy Center for Mental Retardation (1998-2005). Read More
Bethlehem "Betty" Bekele
Graduate Student (PhD program, Neuroscience)
bethlehem.bekele@emory.edu
My current research is focused on understanding the molecular and neurobiological mechanisms that contribute to brain pathology in Myotonic Dystrophy Type 1 (DM1). I use the Muscleblind-like protein 2 (MBNL2)- deficient DM1 mouse model as well as patient-derived induced pluripotent stem cells (iPSCs) to study CNS deficits DM1. The findings from my research will help design novel therapies that mitigate the behavioral/cognitive impact of the disease.
Mingee "Tony" Chung
Research Specialist
tony.chung@emory.edu
My interests revolve around the overlapping genetics and pathogenesis that lead to C9 ALS/FTD. As a research specialist, I am working jointly with Zachary McEachin to understand the role of chimeric dipeptide repeats in C9orf72-ALS/FTD pathogenesis. More broadly we are interested in understanding splicing defects associated with TDP-43 proteinopathies. By utilizing model systems such as patient-specific induced pluripotent stem cells (iPSCs), organoid models, and patient tissues, we are attempting to uncover and model the disease pathway underlying C9orf72-ALS/FTD.
I’m interested in the mechanisms of structural neuronal plasticity and its contribution to learning, neurodevelopment and pathology. My current research project is focused on mechanisms of mRNA transport, localization and translation in neurons in the context of DM1 (Myotonic Dystrophy type I). For this, I utilize a variety of methods to visualize proteins and mRNA granules in living and fixed cells.
Luke Knudson
Graduate Student (PhD program, Biomedical Engineering)
luke.knudson@emory.edu
I am currently investigating the interaction between Muscleblind-like (MBNL) RNA-binding protein and kinesin motor proteins and the role that this interaction plays in proper localization of mRNA in neurons. mRNA mislocalization due to MBNL nuclear sequestration is one of the major pathogenic contributors to myotonic dystrophy.
Adam Kosti, PhD
Postdoctoral Fellow
akosti@emory.edu
I am broadly interested in how neurons leverage post-transcriptional regulation to control plasticity. My current research is centered around the altered RNA interference pathway in Fragile X Syndrome. Utilizing both animal and human models, I am identifying dysregulated microRNAs in Fragile X neurons. I will subsequently evaluate whether restoring these altered microRNAs will stop Fragile X Syndrome phenotypes, such as excess protein synthesis and neuronal hyperexcitability.
GiaLinh (Linda) Nguyen, MPH
Senior Research Administrative Coordinator
Linda.gia@emory.edu
As the Research Administrative Coordinator for the Bassell Lab, I ensure that the lab is in compliance with Emory’s research policies. My primary duties include overseeing daily lab activities, tracking laboratory expenditures, monitoring grant budgets, ordering laboratory consumables and chemical reagents, and maintaining laboratory records, biosafety manuals, chemical stock, and communal lab space in accordance with laboratory and biosafety regulations. I also assist the graduate students and research staff with various administrative tasks as needed.
Maxine Robinette
Graduate Student (PhD program, Neuroscience)
maxine.robinette@emory.edu
My research focuses on the underlying cellular and molecular mechanisms of 3q29 microdeletion syndrome (3q29Del), a major genetic risk factor for schizophrenia. I am using human iPSC derived neural stem cell models of individuals with the genetic mutation and a diagnosis of schizophrenia to investigate aberrant cellular function and potential downstream outcomes on neuronal development.
Liang Shi, PhD
Associate Scientist
liang.shi@emory.edu
My overall research focuses on understanding mechanisms of axonal mRNA transport and local protein synthesis in neurons. In particular, I am studying the role of the Fragile X Mental Retardation Protein (FMRP) in cultured neurons using fluorescence microscopy and live cell imaging methods. This will expand our understanding of Fragile X Syndrome and promote development of therapeutic strategies.