Publications

2024 Publications

2023 Publications

Purcell RH, Sefik E, Werner E, King AT, Mosley TJ, Merritt-Garza ME, Chopra P, McEachin ZT, Karne S, Raj N, Vaglio BJ, Sullivan D, Firestein BL, Tilahun K, Robinette MI, Warren ST, Wen Z, Faundez V, Sloan SA, Bassell GJ, Mulle JG.Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion. Sci Adv. 2023 Aug 18;9(33):eadh0558. doi: 10.1126/sciadv.adh0558. Epub 2023 Aug 16. PMID: 37585521; PMCID: PMC10431714.

*This publication is also highlighted in Emory News Center.

Wilkerson JR, Ifrim MF, Valdez-Sinon AN, Hahn P, Bowles JE, Molinaro G, Janusz-Kaminska A, Bassell GJ, Huber KM. FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination. Neurobiol Dis. 2023 Apr 28;182:106136. doi: 10.1016/j.nbd.2023.106136. Epub ahead of print. PMID: 37120096.

Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J. Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS. Elife. 2023 Apr 19;12:e85902. doi: 10.7554/eLife.85902. PMID: 37073950; PMCID: PMC10188109.

Hildebrandt RP, Moss KR, Janusz-Kaminska A, Knudson LA, Denes LT, Saxena T, Boggupalli DP, Li Z, Lin K, Bassell GJ, Wang ET. Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes. Nat Commun. 2023;14(1):3427. Published 2023 Jun 9. doi:10.1038/s41467-023-38923-6.

2022 Publications

Ifrim MF, Janusz-Kaminska A, Bassell GJ. Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites. Cell Rep. 2022 Nov 15;41(7):111658. doi: 10.1016/j.celrep.2022.111658. PMID: 36384114.

Edokpolor KS, Banerjee A, McEachin ZT, Gu J, Kosti A, Arboleda JD, García PS, Wang ET, Bassell GJ. Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy. eNeuro. 2022 Oct 10;9(5):ENEURO.0218-22.2022. doi: 10.1523/ENEURO.0218-22.2022. PMID: 36150891; PMCID: PMC9557336.
*This publication is also reported by the Emory News Center.

Kang Y, Zhou Y, Li Y, Han Y, Xu J, Niu W, Li Z, Liu S, Feng H, Huang W, Duan R, Xu T, Raj N, Zhang F, Dou J, Xu C, Wu H, Bassell GJ, Warren ST, Allen EG, Jin P, Wen Z. A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies. Nat Neurosci. 2021 Oct;24(10):1377-1391. doi: 10.1038/s41593-021-00913-6. Epub 2021 Aug 19. PMID: 34413513; PMCID: PMC8484073.

Pant DC, Parameswaran J, Rao L, Loss I, Chilukuri G, Parlato R, Shi L, Glass JD, Bassell GJ, Koch P, Yilmaz R, Weishaupt JH, Gennerich A, Jiang J. ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain-of-function. EMBO Rep. 2022 Aug 3;23(8):e54234. doi: 10.15252/embr.202154234. Epub 2022 Jun 23. PMID: 35735139; PMCID: PMC9346498.

Bülow P, Segal M, Bassell GJ. Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome. Int J Mol Sci. 2022 Jun 5;23(11):6315. doi: 10.3390/ijms23116315. PMID: 35682993; PMCID: PMC9181819.

Pollak RM, Purcell RH, Rutkowski TP, Malone T, Pachura KJ, Bassell GJ, Epstein MP, Dawson PA, Smith MR, Jones DP, Zwick ME, Warren ST, Caspary T, Weinshenker D, Mulle JG. Metabolic effects of the schizophrenia-associated 3q29 deletion. Transl Psychiatry. 2022 Feb 17;12(1):66. doi: 10.1038/s41398-022-01824-1. PMID: 35177588.

2021 Publications

Bülow P, Wenner PA, Faundez V, Bassell GJ. Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome. Front Cell Dev Biol. 2021 Jul 19;9:702020. doi: 10.3389/fcell.2021.702020. PMID: 34350185; PMCID: PMC8327182.

Sefik E, Purcell RH; Emory 3q29 Project, Walker EF, Bassell GJ, Mulle JG. Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome. Transl Psychiatry. 2021 Jun 15;11(1):357. doi: 10.1038/s41398-021-01435-2. PMID: 34131099; PMCID: PMC8206125.

Abreha MH, Ojelade S, Dammer EB, McEachin ZT, Duong DM, Gearing M, Bassell GJ, Lah JJ, Levey AI, Shulman JM, Seyfried NT. TBK1 interacts with tau and enhances neurodegeneration in tauopathy. J Biol Chem. 2021 Jan-Jun;296:100760. doi: 10.1016/j.jbc.2021.100760. Epub 2021 May 7. PMID: 33965374; PMCID: PMC8191334.

Bülow P, Zlatic SA, Wenner PA, Bassell GJ, Faundez V. FMRP attenuates activity dependent modifications in the mitochondrial proteome. Mol Brain. 2021 Apr 30;14(1):75. doi: 10.1186/s13041-021-00783-w. PMID: 33931071; PMCID: PMC8086361.

Rutkowski TP, Purcell RH, Pollak RM, Grewenow SM, Gafford GM, Malone T, Khan UA, Schroeder JP, Epstein MP, Bassell GJ, Warren ST, Weinshenker D, Caspary T, Mulle JG. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Mol Psychiatry. 2021 Mar;26(3):772-783. doi: 10.1038/s41380-019-0413-5. Epub 2019 Apr 11. PMID: 30976085; PMCID: PMC6788962.

Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, Wolf-Ochoa MW, Martinez-Cerdeño V, Wernig M, Chen L, Klann E, Warren ST, Jin P, Wen Z, Bassell GJ. Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis. Cell Rep. 2021 Apr 13;35(2):108991. doi: 10.1016/j.celrep.2021.108991. PMID: 33852833; PMCID: PMC8133829.

*Highlight of article in Spectrum News.

Bakkar N, Starr A, Rabichow BE, Lorenzini I, McEachin ZT, Kraft R, Chaung M, Macklin-Isquierdo S, Wingfield T, Carhart B, Zahler N, Chang WH, Bassell GJ, Betourne A, Boulis N, Alworth SV, Ichida JK, August PR, Zarnescu DC, Sattler R, Bowser R. The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease. Neurobiol Dis. 2021 Feb;149:105228. doi: 10.1016/j.nbd.2020.105228. Epub 2020 Dec 24. PMID: 33359139.

Shapiro LP, Pitts EG, Li DC, Barbee BR, Hinton EA, Bassell GJ, Gross C, Gourley SL. The PI3-Kinase p110β Isoform Controls Severity of Cocaine-Induced Sequelae and Alters the Striatal Transcriptome. Biol Psychiatry. 2021 May 15;89(10):959-969. doi: 10.1016/j.biopsych.2021.01.008. Epub 2021 Jan 27. PMID: 33773752; PMCID: PMC8202243.

2020 Publications

Johnson MA, Deng Q, Taylor G, McEachin ZT, Chan AWS, Root J, Bassell GJ, Kukar T. Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage. Neurobiol Dis. 2020 Dec;146:105085. doi: 10.1016/j.nbd.2020.105085. Epub 2020 Sep 18. PMID: 32950644; PMCID: PMC8064403.

McEachin ZT, Parameswaran J, Raj N, Bassell GJ, Jiang J. RNA-mediated toxicity in C9orf72 ALS and FTD. Neurobiol Dis. 2020 Nov;145:105055. Epub 2020/08/21. doi: 10.1016/j.nbd.2020.105055. PubMed PMID: 32829028; PMCID: PMC7572710.

Valdez-Sinon AN, Gokhale A, Faundez V, Bassell GJ. Protocol for Immuno-Enrichment of FLAG-Tagged Protein Complexes. STAR Protocols. 2020 Sep 18; 1(2):100083. Epub 2020/08/11. doi: 10.1016/j.xpro.2020.100083.

Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, Wyllie DJA. Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. Mol Autism. 2020 Jun 19;11(1):52. doi: 10.1186/s13229-020-00351-4. PMID: 32560741; PMCID: PMC7304215.

Goering R, Hudish LI, Guzman BB, Raj N, Bassell GJ, Russ HA, Dominguez D, Taliaferro JM. FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences. Elife. 2020 Jun 8;9:e52621. doi: 10.7554/eLife.52621. PMID: 32510328; PMCID: PMC7279889.

Lai A, Valdez-Sinon AN, Bassell GJ. Regulation of RNA granules by FMRP and implications for neurological diseases. Traffic. 2020. Epub 2020/05/06. doi: 10.1111/tra.12733. PubMed PMID: 32374065. 

Todd TW, McEachin ZT, Chew J, Burch AR, Jansen-West K, Tong J, Yue M, Song Y, Castanedes-Casey M, Kurti A, Dunmore JH, Fryer JD, Zhang YJ, San Millan B, Teijeira Bautista S, Arias M, Dickson D, Gendron TF, Sobrido MJ, Disney MD, Bassell GJ, Rossoll W, Petrucelli L. Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo. Cell Rep. 2020 May 5;31(5):107616. doi: 10.1016/j.celrep.2020.107616. PubMed PMID: 32375043.

McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ, Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, San Millán B, Teijeira S, Yamashita T, Ohkubo R, Boulis NM, Xu C, Wen Z, Streichenberger N; Neuro–CEB Neuropathology Network, Fogel BL, Kukar T, Abe K, Dickson DW, Arias M, Glass JD, Jiang J, Tansey MG, Sobrido MJ, Petrucelli L, Rossoll W, Bassell GJ. Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36. Neuron. 2020 May 3:S0896-6273(20)30280-4. Epub 2020/05/03. doi: 10.1016/j.neuron.2020.04.011. PubMed PMID: 32375063.

*This publication is also highlighted in Neuron and Emory Health Sciences Research Blog - LabLand. 

Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons Through an FMRP-Dependent Mechanism. iScience. 2020 May 1:101132. doi:10.1016/j.isci.2020.101132

Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis. Nat Neurosci. 2020 Mar;23(3):386-397. Epub 2020/02/17. doi: 10.1038/s41593-020-0590-1. PubMed PMID: 32066985.

Imperatore JA, McAninch DS, Valdez-Sinon AN, Bassell GJ, Mihailescu MR. FUS Recognizes G Quadruplex Structures Within Neuronal mRNAs. Front Mol Biosci. 2020 Feb 7;7:6. doi: 10.3389/fmolb.2020.00006. PubMed PMID: 32118033; PMCID: PMC7018707.

Perszyk RE, Swanger SA, Shelley C, Khatri A, Fernandez-Cuervo G, Epplin MP, Zhang J, Le P, Bülow P, Garnier-Amblard E, Gangireddy PKR, Bassell GJ, Yuan H, Menaldino DS, Liotta DC, Liebeskind LS, Traynelis SF. Biased modulators of NMDA receptors control channel opening and ion selectivity. Nat Chem Biol. 2020 Feb;16(2):188-196. Epub 2020/01/20. doi: 10.1038/s41589-019-0449-5. PubMed PMID: 31959964; PMCID: PMC6986806.

Yun Y, Hong SA, Kim KK, Baek D, Lee D, Londhe AM, Lee M, Yu J, McEachin ZT, Bassell GJ, Bowser R, Hales CM, Cho SR, Kim J, Pae AN, Cheong E, Kim S, Boulis NM, Bae S, Ha Y. CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual. Commun Biol. 2020 Jan 20;3(1):33. doi: 10.1038/s42003-020-0755-1. PMID: 31959876; PMCID: PMC6970999.

2019 Publications

Rutkowski TP, Purcell RH, Pollak RM, Grewenow SM, Gafford GM, Malone T, Khan UA, Schroeder JP, Epstein MP, Bassell GJ, Warren ST, Weinshenker D, Caspary T, Mulle JG. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Molecular Psychiatry. 2019. Epub 2019/04/11. doi: 10.1038/s41380-019-0413-5. PubMed PMID: 30976085. PMCID: PMC6788962.

Whyte AJ, Kietzman HW, Swanson AM, Butkovich LM, Barbee BR, Bassell GJ, Gross C, Gourley SL. Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex. J Neurosci. 2019 June 5;39(23):4595-4605. Epub 2019/04/02. doi: 10.1523/JNEUROSCI.2031-18.2019. PubMed PMID: 30940719; PMCID: PMC6554633.

DeMarco B, Stefanovic S, Williams A, Moss KR, Anderson BR, Bassell GJ, Mihailescu MR. FMRP - G-quadruplex mRNA - miR-125a interactions: Implications for miR-125a mediated translation regulation of PSD-95 mRNA. PLoS One. 2019 May 21;14(5):e0217275. doi: 10.1371/journal.pone.0217275. PubMed PMID: 31112584; PMCID: PMC6529005.

Rossoll W, Bassell GJ. Crosstalk of Local Translation and Mitochondria: Powering Plasticity in Axons and Dendrites. Neuron. 2019;101(2):204-6. doi: 10.1016/j.neuron.2018.12.027. PubMed PMID: 30653934.

Gross C, Banerjee A, Tiwari D, Longo F, White AR, Allen AG, Schroeder-Carter LM, Krzeski JC, Elsayed NA, Puckett R, Klann E, Rivero RA, Gourley SL, Bassell GJ. Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model. Neuropsychopharmacology. 2019;44(2):324-33. Epub 2018/07/13. doi: 10.1038/s41386-018-0150-5. PubMed PMID: 30061744; PMCID: PMC6300538.

*This publication is highlighted in EurekAlert! Click here to read highlight.

Bülow P, Murphy TJ, Bassell GJ, Wenner P. Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons. Cell reports. 2019;26(6):1378-88.e3. doi: 10.1016/j.celrep.2019.01.035. PubMed PMID: 30726724; PMCID: PMC6443253.

2018 Publications

Thomas KT, Gross C, Bassell GJ. microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease. Frontiers in molecular neuroscience. 2018;11:455. Epub 2019/01/09. doi: 10.3389/fnmol.2018.00455. PubMed PMID: 30618607; PMCID: PMC6299112.

Banerjee A, Ifrim MF, Valdez AN, Raj N, Bassell GJ. Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies. Brain research. 2018;1693(Pt A):24-36. Epub 2018/04/14. doi: 10.1016/j.brainres.2018.04.008. PubMed PMID: 29653083.

2017 Publications

Urbanska AS, Janusz-Kaminska A, Switon K, Hawthorne AL, Perycz M, Urbanska M, Bassell GJ, Jaworski J. ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons. Scientific reports. 2017;7(1):1876. Epub 2017/05/14. doi: 10.1038/s41598-017-01963-2. PubMed PMID: 28500298; PMCID: PMC5431813.

 

Thomas KT, Anderson BR, Shah N, Zimmer SE, Hawkins D, Valdez AN, Gu Q, Bassell GJ. Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1alpha Neurodevelopmental Signal Transduction. Cell reports. 2017;20(1):1-12. Epub 2017/07/07. doi: 10.1016/j.celrep.2017.06.038. PubMed PMID: 28683304; PMCID: PMC5745041.

 

Rha J, Jones SK, Fidler J, Banerjee A, Leung SW, Morris KJ, Wong JC, Inglis GAS, Shapiro L, Deng Q, Cutler AA, Hanif AM, Pardue MT, Schaffer A, Seyfried NT, Moberg KH, Bassell GJ, Escayg A, Garcia PS, Corbett AH. The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Human molecular genetics. 2017;26(19):3663-81. Epub 2017/07/02. doi: 10.1093/hmg/ddx248. PubMed PMID: 28666327; PMCID: PMC5886104.

 

McConnell O, Wang E, Bassell G, Moody O, Jenkins A, Freeman A, Trotti LM, Saini P, Rye D. Impaired consciousness states in myotonic dystrophy-type 1 mediation by γ-amino butyric acid (GABA). Sleep medicine. 2017;40:e285. doi: https://doi.org/10.1016/j.sleep.2017.11.836.

 

McAninch DS, Heinaman AM, Lang CN, Moss KR, Bassell GJ, Rita Mihailescu M, Evans TL. Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR. Molecular bioSystems. 2017;13(8):1448-57. Epub 2017/06/15. doi: 10.1039/c7mb00070g. PubMed PMID: 28612854; PMCID: PMC5544254.

 

Lepelletier L, Langlois SD, Kent CB, Welshhans K, Morin S, Bassell GJ, Yam PT, Charron F. Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation. Journal of neuroscience. 2017;37(7):1685-95. Epub 2017/01/12. doi: 10.1523/jneurosci.3016-16.2016. PubMed PMID: 28073938.

 

Ivanova TN, Gross C, Mappus RC, Kwon YJ, Bassell GJ, Liu RC. Familiarity with a vocal category biases the compartmental expression of Arc/Arg3.1 in core auditory cortex. Learning & memory. 2017;24(12):612-21. Epub 2017/11/17. doi: 10.1101/lm.046086.117. PubMed PMID: 29142056; PMCID: PMC5688959.

 

Donlin-Asp PG, Rossoll W, Bassell GJ. Spatially and temporally regulating translation via mRNA-binding proteins in cellular and neuronal function. FEBS letters. 2017;591(11):1508-25. Epub 2017/03/16. doi: 10.1002/1873-3468.12621. PubMed PMID: 28295262.

 

Donlin-Asp PG, Fallini C, Campos J, Chou CC, Merritt ME, Phan HC, Bassell GJ, Rossoll W. The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly. Cell reports. 2017;18(7):1660-73. Epub 2017/02/16. doi: 10.1016/j.celrep.2017.01.059. PubMed PMID: 28199839; PMCID: PMC5492976.

 

Bienkowski RS, Banerjee A, Rounds JC, Rha J, Omotade OF, Gross C, Morris KJ, Leung SW, Pak C, Jones SK, Santoro MR, Warren ST, Zheng JQ, Bassell GJ, Corbett AH, Moberg KH. The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Cell reports. 2017;20(6):1372-84. Epub 2017/08/10. doi: 10.1016/j.celrep.2017.07.038. PubMed PMID: 28793261; PMCID: PMC5577809.

2016 Publications

Williams KR, McAninch DS, Stefanovic S, Xing L, Allen M, Li W, Feng Y, Mihailescu MR, Bassell GJ. hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation. Molecular biology of the cell. 2016;27(3):518-34. Epub 2015/12/15. doi: 10.1091/mbc.E15-07-0504. PubMed PMID: 26658614; PMCID: PMC4751602.

 

Wang ET, Taliaferro JM, Lee JA, Sudhakaran IP, Rossoll W, Gross C, Moss KR, Bassell GJ. Dysregulation of mRNA Localization and Translation in Genetic Disease. The Journal of Neuroscience. 2016;36(45):11418-26. Epub 2016/12/03. doi: 10.1523/jneurosci.2352-16.2016. PubMed PMID: 27911744; PMCID: PMC5125209.

 

Poopal AC, Schroeder LM, Horn PS, Bassell GJ, Gross C. Increased expression of the PI3K catalytic subunit p110delta underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family. Molecular autism. 2016;7:3. Epub 2016/01/16. doi: 10.1186/s13229-015-0066-4. PubMed PMID: 26770665; PMCID: PMC4712554.

 

Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Molecular neurodegeneration. 2016;11(1):46. Epub 2016/06/28. doi: 10.1186/s13024-016-0114-3. PubMed PMID: 27341800; PMCID: PMC4919863.

 

Gross C, Yao X, Engel T, Tiwari D, Xing L, Rowley S, Danielson SW, Thomas KT, Jimenez-Mateos EM, Schroeder LM, Pun RYK, Danzer SC, Henshall DC, Bassell GJ. MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset. Cell reports. 2016;17(1):37-45. Epub 2016/09/30. doi: 10.1016/j.celrep.2016.08.074. PubMed PMID: 27681419; PMCID: PMC5061042.

 

Fallini C, Donlin-Asp PG, Rouanet JP, Bassell GJ, Rossoll W. Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons. Journal of neuroscience. 2016;36(13):3811-20. Epub 2016/04/01. doi: 10.1523/jneurosci.2396-15.2016. PubMed PMID: 27030765; PMCID: PMC4812137.

 

Donlin-Asp PG, Bassell GJ, Rossoll W. A role for the survival of motor neuron protein in mRNP assembly and transport. Current opinion in neurobiology. 2016;39:53-61. Epub 2016/05/02. doi: 10.1016/j.conb.2016.04.004. PubMed PMID: 27131421.

 

Anderson BR, Chopra P, Suhl JA, Warren ST, Bassell GJ. Identification of consensus binding sites clarifies FMRP binding determinants. Nucleic acids research. 2016;44(14):6649-59. Epub 2016/07/06. doi: 10.1093/nar/gkw593. PubMed PMID: 27378784; PMCID: PMC5001617.

2015 Publications

Suhl JA, Muddashetty RS, Anderson BR, Ifrim MF, Visootsak J, Bassell GJ, Warren ST. A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(47):E6553-61. Epub 2015/11/11. doi: 10.1073/pnas.1514260112. PubMed PMID: 26554012; PMCID: PMC4664359.

 

Stefanovic S, DeMarco BA, Underwood A, Williams KR, Bassell GJ, Mihailescu MR. Fragile X mental retardation protein interactions with a G quadruplex structure in the 3'-untranslated region of NR2B mRNA. Molecular bioSystems. 2015;11(12):3222-30. Epub 2015/09/29. doi: 10.1039/c5mb00423c. PubMed PMID: 26412477; PMCID: PMC4643373.

 

Stefanovic S, Bassell GJ, Mihailescu MR. G quadruplex RNA structures in PSD-95 mRNA: potential regulators of miR-125a seed binding site accessibility. Rna. 2015;21(1):48-60. Epub 2014/11/20. doi: 10.1261/rna.046722.114. PubMed PMID: 25406362; PMCID: PMC4274637.

 

Richter JD, Bassell GJ, Klann E. Dysregulation and restoration of translational homeostasis in fragile X syndrome. Nature reviews neuroscience. 2015;16(10):595-605. Epub 2015/09/10. doi: 10.1038/nrn4001. PubMed PMID: 26350240; PMCID: PMC4688896.

 

Ifrim MF, Williams KR, Bassell GJ. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. Journal of neuroscience. 2015;35(18):7116-30. Epub 2015/05/08. doi: 10.1523/jneurosci.2802-14.2015. PubMed PMID: 25948262; PMCID: PMC4420780.

 

Gross C, Raj N, Molinaro G, Allen AG, Whyte AJ, Gibson JR, Huber KM, Gourley SL, Bassell GJ. Selective role of the catalytic PI3K subunit p110beta in impaired higher order cognition in fragile X syndrome. Cell reports. 2015;11(5):681-8. Epub 2015/04/30. doi: 10.1016/j.celrep.2015.03.065. PubMed PMID: 25921527; PMCID: PMC4426038.

 

Gross C, Hoffmann A, Bassell GJ, Berry-Kravis EM. Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back. Neurotherapeutics. 2015;12(3):584-608. Epub 2015/05/20. doi: 10.1007/s13311-015-0355-9. PubMed PMID: 25986746; PMCID: PMC4489963.

 

Gross C, Chang CW, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell reports. 2015;11(5):727-36. Epub 2015/04/30. doi: 10.1016/j.celrep.2015.03.060. PubMed PMID: 25921541; PMCID: PMC4418204.

 

2014 Publications

Zhang Y, Gaetano CM, Williams KR, Bassell GJ, Mihailescu MR. FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA. RNA biology. 2014;11(11):1364-74. Epub 2015/02/19. doi: 10.1080/15476286.2014.996464. PubMed PMID: 25692235; PMCID: PMC4615183.

 

Wigington CP, Williams KR, Meers MP, Bassell GJ, Corbett AH. Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions. Wiley interdisciplinary reviews RNA. 2014;5(5):601-22. Epub 2014/05/03. doi: 10.1002/wrna.1233. PubMed PMID: 24789627; PMCID: PMC4332543.

 

Suhl JA, Chopra P, Anderson BR, Bassell GJ, Warren ST. Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences. Human molecular genetics. 2014;23(20):5479-91. Epub 2014/05/31. doi: 10.1093/hmg/ddu272. PubMed PMID: 24876161; PMCID: PMC4168832.

 

Sasaki Y, Gross C, Xing L, Goshima Y, Bassell GJ. Identification of axon-enriched microRNAs localized to growth cones of cortical neurons. Developmental neurobiology. 2014;74(3):397-406. Epub 2013/07/31. doi: 10.1002/dneu.22113. PubMed PMID: 23897634; PMCID: PMC4111797.

 

Gross C, Bassell GJ. Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders. Frontiers in molecular neuroscience. 2014;7:12. Epub 2014/03/05. doi: 10.3389/fnmol.2014.00012. PubMed PMID: 24592210; PMCID: PMC3923137.

 

Fallini C, Rouanet JP, Donlin-Asp PG, Guo P, Zhang H, Singer RH, Rossoll W, Bassell GJ. Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons. Developmental neurobiology. 2014;74(3):319-32. Epub 2013/07/31. doi: 10.1002/dneu.22111. PubMed PMID: 23897586; PMCID: PMC3906212.

2013 Publications

Xing L, Bassell GJ. mRNA localization: an orchestration of assembly, traffic and synthesis. Traffic. 2013;14(1):2-14. Epub 2012/08/24. doi: 10.1111/tra.12004. PubMed PMID: 22913533; PMCID: PMC3548013.

 

Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD. Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nature medicine. 2013;19(11):1473-7. Epub 2013/10/22. doi: 10.1038/nm.3353. PubMed PMID: 24141422; PMCID: PMC3823751.

 

Swanger SA, He YA, Richter JD, Bassell GJ. Dendritic GluN2A synthesis mediates activity-induced NMDA receptor insertion. Journal of neuroscience. 2013;33(20):8898-908. Epub 2013/05/17. doi: 10.1523/jneurosci.0289-13.2013. PubMed PMID: 23678131; PMCID: PMC3684268.

 

Swanger SA, Bassell GJ. Dendritic protein synthesis in the normal and diseased brain. Neuroscience. 2013;232:106-27. Epub 2012/12/25. doi: 10.1016/j.neuroscience.2012.12.003. PubMed PMID: 23262237; PMCID: PMC4502914.

 

Larimore J, Ryder PV, Kim KY, Ambrose LA, Chapleau C, Calfa G, Gross C, Bassell GJ, Pozzo-Miller L, Smith Y, Talbot K, Park IH, Faundez V. MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons. PloS one. 2013;8(6):e65069. Epub 2013/06/12. doi: 10.1371/journal.pone.0065069. PubMed PMID: 23750231; PMCID: PMC3672180.

 

Jakkamsetti V, Tsai NP, Gross C, Molinaro G, Collins KA, Nicoletti F, Wang KH, Osten P, Bassell GJ, Gibson JR, Huber KM. Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression. Neuron. 2013;80(1):72-9. Epub 2013/10/08. doi: 10.1016/j.neuron.2013.07.020. PubMed PMID: 24094104; PMCID: PMC3801421.

2012 Publications

Xing L, Yao X, Williams KR, Bassell GJ. Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Molecular biology of the cell. 2012;23(8):1500-9. Epub 2012/02/24. doi: 10.1091/mbc.E11-10-0867. PubMed PMID: 22357624; PMCID: PMC3327311.

 

Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu ZS, van den Berg LH, Glass JD, Siciliano G, Cirulli ET, Goldstein DB, Salachas F, Meininger V, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ, Silani V, Drory VE, Brown RH, Jr., Landers JE. Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature. 2012;488(7412):499-503. Epub 2012/07/18. doi: 10.1038/nature11280. PubMed PMID: 22801503; PMCID: PMC3575525.

FEATURED on the EMORY News Center. Familial ALS gene critical for axon growth. 2012. http://news.emory.edu/stories/2012/07/new_gene_linked_with_familial_ALS_critical_for_axon_growth/index.html.

 

Wilhelm JC, Xu M, Cucoranu D, Chmielewski S, Holmes T, Lau KS, Bassell GJ, English AW. Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. Journal of neuroscience. 2012;32(14):5002-9. Epub 2012/04/12. doi: 10.1523/jneurosci.1411-11.2012. PubMed PMID: 22492055; PMCID: PMC3382119.

 

Udagawa T, Swanger SA, Takeuchi K, Kim JH, Nalavadi V, Shin J, Lorenz LJ, Zukin RS, Bassell GJ, Richter JD. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Molecular cell. 2012;47(2):253-66. Epub 2012/06/26. doi: 10.1016/j.molcel.2012.05.016. PubMed PMID: 22727665; PMCID: PMC3408552.

 

Ryder PV, Bassell GJ, Faundez V. An MBoC Favorite: Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Molecular biology of the cell. 2012;23(11):2015-. doi: 10.1091/mbc.e12-02-0154.

 

Nalavadi VC, Muddashetty RS, Gross C, Bassell GJ. Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation. Journal of neuroscience. 2012;32(8):2582-7. Epub 2012/02/24. doi: 10.1523/jneurosci.5057-11.2012. PubMed PMID: 22357842; PMCID: PMC3427762.

 

Nalavadi VC, Griffin LE, Picard-Fraser P, Swanson AM, Takumi T, Bassell GJ. Regulation of zipcode binding protein 1 transport dynamics in axons by myosin Va. Journal of neuroscience. 2012;32(43):15133-41. Epub 2012/10/27. doi: 10.1523/jneurosci.2006-12.2012. PubMed PMID: 23100434; PMCID: PMC3508068.

 

Gross C, Bassell GJ. Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110beta-selective inhibitor. Molecular medicine (Cambridge, Mass). 2012;18:336-45. Epub 2011/12/31. doi: 10.2119/molmed.2011.00363. PubMed PMID: 22207187; PMCID: PMC3356413.

 

Fallini C, Bassell GJ, Rossoll W. Spinal muscular atrophy: the role of SMN in axonal mRNA regulation. Brain research. 2012;1462:81-92. Epub 2012/02/15. doi: 10.1016/j.brainres.2012.01.044. PubMed PMID: 22330725; PMCID: PMC3360984.

 

Fallini C, Bassell GJ, Rossoll W. The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth. Human molecular genetics. 2012;21(16):3703-18. Epub 2012/05/30. doi: 10.1093/hmg/dds205. PubMed PMID: 22641816; PMCID: PMC3406762.

FEATURED on the EMORY Health Sciences Research Blog. Rethinking the role of aggregation –prone protein in ALS. 2012. http://www.emoryhealthsciblog.com/?tag=claudia-fallini.

 

Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ, Seyfried NT. Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination. PloS one. 2012;7(6):e38658. Epub 2012/07/05. doi: 10.1371/journal.pone.0038658. PubMed PMID: 22761693; PMCID: PMC3380899.

 

Ceci M, Welshhans K, Ciotti MT, Brandi R, Parisi C, Paoletti F, Pistillo L, Bassell GJ, Cattaneo A. RACK1 is a ribosome scaffold protein for beta-actin mRNA/ZBP1 complex. PloS one. 2012;7(4):e35034. Epub 2012/04/24. doi: 10.1371/journal.pone.0035034. PubMed PMID: 22523568; PMCID: PMC3327689.