Lab News

@BassellLab Paper by First Author Zachary McEachin et. al. Published in Neuron and Highlighted in Emory Health Sciences Research Blog

McEachin et alThe Bassell Lab published, "Chimeric peptides contribute to divergent DPR pathology in c9ALS/FTD and SCA36," by Zack McEachin and superb collaborators at Emory University School of Medicine, Mayo Clinic Florida, University of Florida and several other universities in the US, Spain and Japan.  

This publication is also highlighted in Emory Health Sciences Research Blog - LabLand. Click here to link to the highlight.

 

@BassellLab Paper by First Author Arielle N. Valdez-Sinon et. al. Published in iScience

Valdez et alThe Bassell and Faundez labs published, "Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons Through an FMRP-Dependent Mechanism," by Arielle N. Valdez-Sinon et al.

 

 

 

Bassell Lab Group

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Highlights

Gary Bassell and Eric Wang Receive NINDS Funding for Collaborative Research on Myotonic Dystrophy

Drs. Bassell and Wang The National Institute of Neurological Disorders and Stroke has awarded Bassell’s and Wang’s laboratories $2.2 million over five years to examine the neuronal function of Muscleblind-like proteins, which play key roles in myotonic dystrophy.

Read full story in Emory Health Sciences Blog.

LISTEN to a joint talk recently presented by Gary Bassell and Eric Wang at the RNA Society annual meeting in May 2020.

Recent Publications

Valdez-Sinon AN, Gokhale A, Faundez V, Bassell GJ. Protocol for Immuno-Enrichment of FLAG-Tagged Protein Complexes. STAR Protocols. 2020 Sep 18; 1(2):100083. Epub 2020/08/11. doi: 10.1016/j.xpro.2020.100083.

McEachin ZT, Parameswaran J, Raj N, Bassell GJ, Jiang J. RNA-mediated toxicity in C9orf72 ALS and FTD. Neurobiol Dis. 2020 Nov;145:105055. Epub 2020/08/21. doi: 10.1016/j.nbd.2020.105055. PubMed PMID: 32829028; PMCID: PMC7572710.

Lai A, Valdez-Sinon AN, Bassell GJ. Regulation of RNA granules by FMRP and implications for neurological diseases. Traffic. 2020. Epub 2020/05/06. doi: 10.1111/tra.12733. PubMed PMID: 32374065. 

Todd TW, McEachin ZT, Chew J, Burch AR, Jansen-West K, Tong J, Yue M, Song Y, Castanedes-Casey M, Kurti A, Dunmore JH, Fryer JD, Zhang YJ, San Millan B, Teijeira Bautista S, Arias M, Dickson D, Gendron TF, Sobrido MJ, Disney MD, Bassell GJ, Rossoll W, Petrucelli L. Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo. Cell Rep. 2020 May 5;31(5):107616. doi: 10.1016/j.celrep.2020.107616. PMID: 32375043.

Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons Through an FMRP-Dependent MechanismiScience (2020), doi: https://doi.org/10.1016/j.isci.2020.101132.

McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ, Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, San Millán B, Teijeira S, Yamashita T, Ohkubo R, Boulis NM, Xu C, Wen Z, Streichenberger N, Fogel BL, Kukar T, Abe K, Dickson DW, Arias M, Glass JD, Jiang J, Tansey MG, Sobrido M, Petrucelli L, Rossoll W, Bassell GJ. Chimeric peptides contribute to divergent DPR pathology in c9ALS/FTD and SCA36. Neuron 2020 May 05, DOI:https://doi.org/10.1016/j.neuron.2020.04.011.

Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis. Nat Neurosci. 2020 Mar;23(3):386-397. Epub 2020/02/17. doi: 10.1038/s41593-020-0590-1. PubMed PMID: 32066985.

Perszyk RE, Swanger SA, Shelley C, Khatri A, Fernandez-Cuervo G, Epplin MP, Zhang J, Le P, Bülow P, Garnier-Amblard E, Gangireddy PKR, Bassell GJ, Yuan H, Menaldino DS, Liotta DC, Liebeskind LS, Traynelis SF. Biased modulators of NMDA receptors control channel opening and ion selectivity. Nat Chem Biol. 2020 Feb;16(2):188-196. Epub 2020/01/20. doi: 10.1038/s41589-019-0449-5. PubMed PMID: 31959964; PMCID: PMC6986806.

Imperatore JA, McAninch DS, Valdez-Sinon AN, Bassell GJ, Mihailescu MR. FUS Recognizes G Quadruplex Structures Within Neuronal mRNAs. Front Mol Biosci. 2020 Feb 7;7:6. doi: