Lab News

@BassellLab Paper by First Author Kamyra Edokpolor et. al. Published in eNeuro

The Bassell Lab published, "Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy," by Kamyra Edopolor et al.

This publication is also highlighted in Emory News Center.


@BassellLab Paper by Paper by First Author Marius Ifrim et. al. Published in Cell Reports

The Bassell Lab published, "Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites,” by Marius Ifrim et al.

 

 

 

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In MEMORY OF KUN LIN

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With a heavy heart we communicate the recent tragic passing of my graduate student, our colleague and friend, Kun Lin, on February 12, 2021. Our tears and sadness are hard. Kun was full of radiant energy, intellect and passion, kind and generous, with dreams to become a professor. To learn more about Kun's short but wonderful life, to share your thoughts and contributions:

GOFUNDME - To provide support to Kun's parents for medical, funeral, and other costs, please visit.

KUDOBOARD - to share your thoughts and photos about Kun.

KUN LIN MEMORIAL SCHOLARSHIP FUND

MEMORIAL BENCH - To contribute to the Kun Lin Memorial Bench, please donate to the Atlanta Botanical Garden (Kun’s favorite place in Atlanta, GA). Please indicate donations are “In memory of Kun Lin”.

THE KUN LIN MEMORIAL LECTURE:

We are grateful for the kind and generous donations from faculty, students and friends to establish the Kun Lin Memorial lecture. The lecture topics will relate to Kun's research interests in cellular and brain imaging, and RNA and synapse biology in health and disease.

-Gary J. Bassell, PhD, Professor and Chair

Highlights

Gary Bassell and Eric Wang Receive NINDS Funding for Collaborative Research on Myotonic Dystrophy

Drs. Bassell and Wang The National Institute of Neurological Disorders and Stroke has awarded Bassell’s and Wang’s laboratories $2.2 million over five years to examine the neuronal function of Muscleblind-like proteins, which play key roles in myotonic dystrophy.

Read full story in Emory Health Sciences Blog.

LISTEN to a joint talk recently presented by Gary Bassell and Eric Wang at the RNA Society annual meeting in May 2020.

Recent Publications

Ifrim MF, Janusz-Kaminska A, Bassell GJ. Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites. Cell Rep. 2022 Nov 15;41(7):111658. doi: 10.1016/j.celrep.2022.111658. PMID: 36384114.

Edokpolor KS, Banerjee A, McEachin ZT, Gu J, Kosti A, Arboleda JD, García PS, Wang ET, Bassell GJ. Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy. eNeuro. 2022 Oct 10;9(5):ENEURO.0218-22.2022. doi: 10.1523/ENEURO.0218-22.2022. PMID: 36150891; PMCID: PMC9557336.
*This publication is also reported by the Emory News Center.

Kang Y, Zhou Y, Li Y, Han Y, Xu J, Niu W, Li Z, Liu S, Feng H, Huang W, Duan R, Xu T, Raj N, Zhang F, Dou J, Xu C, Wu H, Bassell GJ, Warren ST, Allen EG, Jin P, Wen Z. A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies. Nat Neurosci. 2021 Oct;24(10):1377-1391. doi: 10.1038/s41593-021-00913-6. Epub 2021 Aug 19. PMID: 34413513; PMCID: PMC8484073.

Pant DC, Parameswaran J, Rao L, Loss I, Chilukuri G, Parlato R, Shi L, Glass JD, Bassell GJ, Koch P, Yilmaz R, Weishaupt JH, Gennerich A, Jiang J. ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain-of-function. EMBO Rep. 2022 Aug 3;23(8):e54234. doi: 10.15252/embr.202154234. Epub 2022 Jun 23. PMID: 35735139; PMCID: PMC9346498.

Bülow P, Segal M, Bassell GJ. Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome. Int J Mol Sci. 2022 Jun 5;23(11):6315. doi: 10.3390/ijms23116315. PMID: 35682993; PMCID: PMC9181819.

Pollak RM, Purcell RH, Rutkowski TP, Malone T, Pachura KJ, Bassell GJ, Epstein MP, Dawson PA, Smith MR, Jones DP, Zwick ME, Warren ST, Caspary T, Weinshenker D, Mulle JG. Metabolic effects of the schizophrenia-associated 3q29 deletion. Transl Psychiatry. 2022 Feb 17;12(1):66. doi: 10.1038/s41398-022-01824-1. PMID: 35177588.

Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, Wolf-Ochoa MW, Martinez-Cerdeño V, Wernig M, Chen L, Klann E, Warren ST, Jin P, Wen Z, Bassell GJ. Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesisCell Rep. 2021 Apr 13;35(2):108991. doi: 10.1016/j.celrep.2021.108991. PMID: 33852833; PMCID: PMC8133829.